Myosin Kinase Inhibiting Peptide CAS NO.119386-39-9
Myosin Kinase Inhibiting Peptide CAS NO.119386-39-9
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Myosin Kinase Inhibiting Peptide |
| CAS NO. | 119386 - 39 - 9 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C40H78N18O11 |
| Molecular Weight | 987.2 g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water or phosphate - buffered |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Myosin Kinase Inhibiting Peptide is a highly specific inhibitor of myosin kinase. In vitro studies have shown that it can effectively block the kinase activity, thereby interfering with the phosphorylation - mediated signaling pathways downstream of myosin kinase. This inhibition can lead to the modulation of muscle contraction, cell migration, and other cellular functions that are regulated by myosin kinase activity. |
| Storage Conditions | Stored at - 20°C in a dry environment. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Targeted Kinase Inhibition: Binds directly to myosin kinase catalytic domains, blocking ATP binding and phosphorylation cascades.
Pathway Modulation: Disrupts downstream signaling responsible for actin-myosin contraction, cell migration, and proliferation.
Reversible Dynamics: Exhibits dose-dependent inhibition with rapid reversibility upon washout, ideal for reversible cellular assays.
2.PRODUCT INDICATIONS
Muscle Physiology Research: Investigates excitation-contraction coupling in skeletal/cardiac muscles.
Cancer Therapeutics: Evaluates anti-metastatic potential by inhibiting tumor cell motility.
Neurodegenerative Studies: Examines microtubule dynamics in neuroblastoma and ALS models.
Drug Screening: Serves as a reference compound for kinase inhibitor pipelines.
3.CLINICAL EFFICACY OF PRODUCT
In Vitro: Achieved 85% kinase inhibition (IC50: 50 nM) in HEK293 cells transfected with myosin kinase constructs.
Ex Vivo: Reduced arterial smooth muscle contraction by 70% in rabbit aorta tissue assays.
Oncology Models: Slowed metastasis in murine melanoma xenografts by 40% (p<0.01) when="" combined="" with="" chemotherapeutics="">.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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