HBV core protein (128-140)
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | GLP-2 (rat) |
| CAS NO. | 95262-56-7 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C66H103N17O17 |
| Molecular Weight | 1406.64g/mol |
| Purity (RP-HPLC) | ≥95% |
| Solubility | Soluble in water, 0.1% TFA, or PBS buffer (pH 7.2-7.4); up to 10 mg/mL |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Specifically recognized by anti-HBV core protein monoclonal/polyclonal antibodies |
| Storage Conditions | Store at -20°C in desiccated condition; stable for 24 months. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This peptide functions as a specific antigenic target for the host immune system. As part of the HBV core protein (HBcAg), this sequence is naturally processed and presented by antigen-presenting cells during HBV infection. The peptide can be presented by major histocompatibility complex (MHC) class II molecules to CD4+ helper T cells, stimulating B-cell help and antibody production. More importantly, it contains epitopes that can also be presented by MHC class I molecules to CD8+ cytotoxic T lymphocytes (CTLs).
- HBV Immunology Research: Mapping B-cell and T-cell epitopes within the HBV core antigen to understand correlates of protective immunity and viral clearance.
- T-Cell Response Monitoring: Serving as a stimulus in enzyme-linked immunospot (ELISPOT) assays, intracellular cytokine staining (ICS), or proliferation assays to detect and quantify HBV-specific CD4+ and CD8+ T-cell responses in patient samples.
- Antibody Detection & Development: Coating plates in enzyme-linked immunosorbent assays (ELISAs) to detect anti-HBc antibodies in serum (anti-HBc detection) or to generate and screen monoclonal antibodies specific to this immunodominant region.
- Vaccine Research: Evaluating the immunogenicity of this specific epitope in preclinical vaccine studies, either as a component of peptide-based vaccines or to assess immune responses elicited by traditional HBV vaccines.
2.PRODUCT INDICATIONS
- Diagnostic Significance: Immune responses against this epitope are central to clinical diagnostics. The presence of antibodies to HBcAg (anti-HBc) is a key serological marker for diagnosing past or ongoing HBV infection. This peptide can be used in research to develop sensitive and specific anti-HBc assays.
- Immunological Correlate: Strong and multispecific T-cell responses, including those targeting this core region, are associated with viral control and clearance in acute HBV infection and in patients who successfully respond to therapy. This peptide is used to monitor these responses in research settings.
- Vaccine Context: While current prophylactic HBV vaccines are based on the surface antigen (HBsAg), therapeutic vaccine strategies aim to induce robust T-cell responses against core and polymerase antigens. This peptide is used in research to evaluate such therapeutic vaccine candidates.
3.CLINICAL EFFICACY OF PRODUCT
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
