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HBV env (335 – 343)

HBV env (335-343) is a high-purity synthetic peptide representing the HLA-A0201-restricted cytotoxic T lymphocyte (CTL) epitope of Hepatitis B virus envelope protein. This 9-amino acid peptide (LLVLTLLGI) corresponds to residues 335-343 of the HBV envelope (HBsAg/pre-S) protein and serves as an immunogenic epitope recognized by CD8⁺ T cells. Manufactured under stringent quality controls with HPLC-verified purity and comprehensive analytical documentation, this product provides researchers with a specialized tool for studying HBV-specific immune responses, T cell activation, and vaccine development. The peptide's affinity for HLA-A0201 makes it valuable for immunology research, T cell monitoring, and therapeutic vaccine evaluation in HLA-A*0201-positive contexts.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	HBV env (335 - 343)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C56H84N10O11
Molecular Weight	1073.35g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in DMSO, PBS (pH 7-8), or physiological saline.
Endotoxin	< 1.0 EU/mg
Biological Activity	The HLA-A*0201-restricted CTL epitope of the hepatitis B virus envelope protein (HBsAg/pre-S) can induce HBV-specific CD8⁺ T cell immune responses, and can be used for HBV immunology research, vaccine development and T cell therapy.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

HBV env (335-343) functions as an MHC class I-restricted epitope that is processed by antigen-presenting cells and presented on HLA-A0201 molecules. The peptide binds to the peptide-binding groove of HLA-A0201, forming stable MHC-peptide complexes on the cell surface. These complexes are recognized by T cell receptors (TCRs) on CD8⁺ cytotoxic T lymphocytes, leading to T cell activation, proliferation, and effector functions including cytokine production (IFN-γ, TNF-α) and cytotoxic activity against HBV-infected cells presenting this epitope. The peptide's specific sequence (LLVLTLLGI) contains anchor residues that confer binding affinity to HLA-A*0201, enabling efficient T cell recognition and immune response induction.

2.PRODUCT INDICATIONS

T Cell Activation Studies: Evaluation of CD8⁺ T cell activation, proliferation, and cytokine production

Vaccine Development: Assessment of envelope-targeted vaccine immunogenicity and T cell responses

Immune Monitoring: Detection of HBV envelope-specific T cells using ELISPOT, MHC tetramer staining, or intracellular cytokine staining

TCR Screening: Identification and validation of T cell receptors specific for HBV envelope epitopes

Therapeutic Vaccine Research: Development of T cell-based immunotherapies targeting HBV envelope

HBV Immunology Research: Investigation of envelope-specific T cell responses and immune mechanisms

3.CLINICAL EFFICACY OF PRODUCT

Sequence Accuracy: Verified 9-amino acid sequence (LLVLTLLGI) corresponding to HBV envelope 335-343

Biological Activity: Validated in T cell activation assays, MHC binding assays, and immune monitoring applications

Research Reproducibility: Consistent performance in functional assays across multiple batches

Quality Documentation: Certificate of Analysis provided with purity, mass spec, and analytical data

Technical Support: Access to application guidance for immunology research and T cell assays

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.