HBV core14, (HBA31)
HBV core14, (HBA31)
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | HBV core14, (HBA31) |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C53H95N17O18 |
| Molecular Weight | 1258.45g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, DMSO, or dilute aqueous buffers (e.g., PBS) |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Research peptide derived from HBV core protein, used to study viral immunity and T-cell responses |
| Storage Conditions | Store at -20°C. Keep tightly closed and protect from moisture; stable for 2 years when stored properly. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This peptide functions as a defined antigenic target for the adaptive immune system. During a natural HBV infection, antigen-presenting cells process the viral core protein and present fragments like the Core14/HBA31 epitope on Major Histocompatibility Complex (MHC) molecules. When presented by MHC class II, this epitope can activate CD4+ helper T cells, which are crucial for supporting B-cell antibody production and CD8+ T-cell functions.
- HBV-Specific T-Cell Monitoring: Serving as a stimulus in immune monitoring assays such as Enzyme-Linked Immunospot (ELISPOT) for interferon-gamma (IFN-γ), intracellular cytokine staining (ICS) by flow cytometry, or proliferation assays to quantify and characterize HBV Core14-specific T-cell responses in patient samples (e.g., chronically infected, vaccinated, or resolved individuals).
- Epitope-Specific Antibody Detection: Coating ELISA plates to detect and measure antibodies specifically targeting the Core14 epitope in human serum, aiding in detailed immune profiling.
- Vaccine Immunology: Evaluating the immunogenicity of the Core14 epitope in preclinical studies of therapeutic HBV vaccine candidates, often as part of a peptide cocktail or a DNA vaccine construct, to assess its ability to induce cellular immunity.
- Immune Escape & Viral Mutation Studies: Investigating how mutations within this epitope region affect T-cell or antibody recognition, which is relevant for understanding viral persistence and immune escape in chronic hepatitis B.
- Reagent for Antibody Generation: Conjugating to a carrier protein to generate monoclonal or polyclonal antibodies specific for this region of the HBV core antigen for use in research or diagnostic assays.
2.PRODUCT INDICATIONS
- Research & Diagnostic Tool Efficacy: Its "efficacy" is its ability to accurately and sensitively detect and quantify HBV-specific T-cell and B-cell responses in research settings, providing valuable immunological data.
- Correlate of Immune Control: In clinical research, strong and multispecific T-cell responses against core epitopes, including those in the Core14 region, are associated with viral clearance in acute infection and with functional cure or immune control in chronic infection. This peptide is used to measure these responses.
- Therapeutic Vaccine Development: The Core14 epitope is a candidate component in investigational therapeutic vaccines for chronic hepatitis B. These vaccines aim to break immune tolerance and restore effective T-cell responses. This peptide is used to design, test, and monitor the immunogenicity of such vaccines in preclinical and clinical trials.
- Clinical Monitoring: Assays using this and similar peptides are used in research to monitor immune reconstitution in patients undergoing antiviral therapy or novel immunotherapies, providing insights into treatment efficacy.
3.CLINICAL EFFICACY OF PRODUCT
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Nov 05, 26
Global Market Analysis and Oxandrolone 50mg Price Guide
For B2B pharmaceutical buyers and researchers, understanding the oxandrolone 50mg price involves analyzing more than just a numerical value; it requires a comprehensive look at API purity, synthesis methods, and global supply chain stability. As a specialized anabolic steroid derivative, the cost is heavily influenced by the quality of raw materials and the rigor of the laboratory testing involved in the production process. This article explores the economic and technical variables that dictate market pricing for this specific compound. In the context of the global API market, pricing volatility is often tied to regulatory shifts in key manufacturing hubs
Nov 04, 26
How to Select High Purity Alisol C CAS 30489271 for Laboratory Research
High Purity Alisol C CAS 30489271 is suited to laboratories using Alisol C as a triterpenoid reference standard in metabolic, hepatology, pharmacology, HPLC/MS, botanical-extract, or selected cell-line research. We explain the application fit and the identity, purity, physical form, solvent, endotoxin, storage, quantity, and batch-record checks to make before ordering.
Nov 02, 26
Reliable Oxandrolone Supplier for High Purity Pharmaceutical APIs
When sourcing high-purity pharmaceutical ingredients for endocrine or cardiovascular research, the reliability of the supply chain is as critical as the chemical purity itself. For laboratories and manufacturers seeking a dependable oxandrolone supplier, the focus must extend beyond simple certificates of analysis to encompass consistent batch-to-batch stability and strict adherence to GMP standards. Whether the requirement is for small-scale pilot studies or large-scale industrial production, the ability to trace materials from raw synthesis to final lyophilized powder ensures the integrity of the resulting clinical or research data.