Hepatitis Virus C NS3 Protease Inhibitor 1
Hepatitis Virus C NS3 Protease Inhibitor 1
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Hepatitis Virus C NS3 Protease Inhibitor 1 |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C29H45N6O16S2 |
| Molecular Weight | 796.8g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in DMSO (≥20 mg/mL), methanol, and dimethylformamide (DMF); sparingly soluble in water |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Potent and selective inhibitor of HCV NS3/4A serine protease, with an IC₅₀ value of ~15 nM; inhibits viral replication in HCV-infected cells, used in anti-HCV drug discovery and mechanism studies. |
| Storage Conditions | Store at -20°C in a dry, inert atmosphere; protect from light and moisture. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This inhibitor functions as a potent, competitive antagonist of the HCV NS3/4A serine protease. It directly binds to the enzyme's active site with high affinity, mimicking the substrate's transition state. By occupying the catalytic cleft where polyprotein cleavage normally occurs, it competitively blocks the protease's ability to bind and process its natural polypeptide substrates.
- In VitroAntiviral Screening: Assessing inhibitory activity against HCV NS3/4A protease enzymatic function in biochemical assays using recombinant protein and fluorogenic peptide substrates.
- Replicon System Studies: Evaluating antiviral efficacy and potency in HCV subgenomic or full-length replicon cell culture systems, which model viral RNA replication.
- Mechanism of Action (MOA) Studies: Serving as a reference control to study NS3 protease function, cleavage kinetics, and resistance mechanisms.
- Combination Therapy Research: Investigating synergistic or additive effects when used in combination with other classes of HCV inhibitors (e.g., NS5A inhibitors, NS5B polymerase inhibitors, nucleos(t)ide analogs) in vitro.
- Resistance Profiling: Selecting for and characterizing viral variants with reduced susceptibility to understand potential resistance pathways and cross-resistance profiles.
- Preclinical Drug Development: Acting as a benchmark compound in the discovery and optimization of next-generation NS3 protease inhibitors.
2.PRODUCT INDICATIONS
- In VitroAntiviral Screening: Assessing inhibitory activity against HCV NS3/4A protease enzymatic function in biochemical assays using recombinant protein and fluorogenic peptide substrates.
- Replicon System Studies: Evaluating antiviral efficacy and potency in HCV subgenomic or full-length replicon cell culture systems, which model viral RNA replication.
- Mechanism of Action (MOA) Studies: Serving as a reference control to study NS3 protease function, cleavage kinetics, and resistance mechanisms.
- Combination Therapy Research: Investigating synergistic or additive effects when used in combination with other classes of HCV inhibitors (e.g., NS5A inhibitors, NS5B polymerase inhibitors, nucleos(t)ide analogs) in vitro.
- Resistance Profiling: Selecting for and characterizing viral variants with reduced susceptibility to understand potential resistance pathways and cross-resistance profiles.
- Preclinical Drug Development: Acting as a benchmark compound in the discovery and optimization of next-generation NS3 protease inhibitors.
3.CLINICAL EFFICACY OF PRODUCT
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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