Hepatitis B Virus Pre-S Region (120-145) CAS NO.104504-34-9

Hepatitis B Virus Pre-S Region (120-145) is a high-purity synthetic peptide corresponding to a key functional domain of the HBV Pre-S antigen, spanning residues 120 to 145. This 26-amino acid peptide represents a critical region involved in viral attachment, host cell receptor binding, and immune recognition. Manufactured under stringent quality controls with HPLC-verified purity and comprehensive analytical documentation, this product provides researchers with a specialized tool for studying HBV pathogenesis, viral entry mechanisms, and host immune responses. Ideal for vaccine development, therapeutic antibody screening, and diagnostic assay design, this peptide enables cutting-edge research in virology, immunology, and antiviral drug discovery.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Hepatitis B Virus Pre-S Region (120-145)
CAS NO.	104504-34-9
Appearance	White to off-white lyophilized powder
Molecular Formula	C135H199N39O38S
Molecular Weight	3008.4g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in DMSO, PBS (pH 7-8), or an aqueous solution containing an organic solvent.
Endotoxin	< 1.0 EU/mg
Biological Activity	Immunoreactive peptides from the HBV Pre-S antigen region; capable of inducing B cell and T cell immune responses, used for HBV vaccine development, antibody screening, immune detection, and immune mechanism research.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The Hepatitis B Virus Pre-S Region (120-145) functions as a crucial domain within the HBV envelope that mediates viral attachment and entry into hepatocytes. This peptide region contains specific binding motifs that interact with host cell surface receptors, particularly the sodium taurocholate co-transporting polypeptide (NTCP), facilitating viral docking and internalization. Additionally, this region plays a significant role in immune evasion and contains epitopes recognized by neutralizing antibodies. The peptide can be used to study receptor-ligand interactions, viral tropism, and the molecular basis of HBV infection. Its structured amino acid sequence maintains conformational properties important for biological activity, making it valuable for functional studies of viral entry and host-pathogen interactions.

2.PRODUCT INDICATIONS

Viral Entry Research: Investigation of HBV attachment, receptor binding, and cellular internalization mechanisms

Vaccine Development: Evaluation of Pre-S immunogenicity and design of novel HBV vaccines

Therapeutic Antibody Screening: Identification and characterization of neutralizing antibodies targeting the Pre-S region

Diagnostic Assay Development: Design of sensitive immunoassays for HBV detection and serological profiling

Pathogenesis Studies: Analysis of Pre-S region functions in HBV persistence, immune evasion, and disease progression

Antiviral Drug Discovery: Screening for compounds that block Pre-S-mediated viral entry or host interactions

3.CLINICAL EFFICACY OF PRODUCT

Sequence Accuracy: Verified 26-amino acid sequence corresponding to HBV Pre-S (120-145) of specified genotype

Biological Relevance: Maintains key functional properties of the native Pre-S region for virological studies

Research Reproducibility: Consistent performance in binding assays, immunological studies, and functional experiments

Quality Documentation: Certificate of Analysis provided with purity, mass spec, and analytical data

Technical Support: Access to application guidance for virology and immunology research

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.