TECHNICAL SPECIFICATIONS

1.MECHANISM OF ACTION

This peptide functions as a defined linear antigenic determinant for the immune system. In vivo, during HCV infection, the full-length core protein is processed by antigen-presenting cells and presented as peptide fragments on Major Histocompatibility Complex (MHC) molecules. The (107-114) region contains potential epitopes that can be presented by specific MHC class I or class II molecules, thereby stimulating HCV-specific T-cell responses. As an exogenous synthetic reagent, the peptide is used to probe these responses. 

2.PRODUCT INDICATIONS

• T-Cell Epitope Mapping & Validation: Determining if this specific region contains immunogenic epitopes recognized by CD8+ cytotoxic T lymphocytes (CTLs) or CD4+ helper T cells in individuals with different HLA types.

• Immune Response Monitoring: Serving as a stimulus in T-cell assays such as Enzyme-Linked Immunospot (ELISPOT) for interferon-gamma (IFN-γ) or intracellular cytokine staining (ICS) to measure the frequency and function of core-specific T cells in HCV-infected or vaccinated subjects.

• Antibody Detection & Analysis: Used as a coating antigen in peptide-based ELISA to detect and characterize anti-core antibodies targeting this specific linear epitope, which may be relevant for serological studies and assay development.

• Vaccine Research: Evaluating the immunogenicity of this specific core protein region as a potential component in peptide-based or multi-epitope vaccine strategies designed to elicit cellular immunity against HCV.

• Protein-Protein Interaction Studies: Potentially used as a probe or competitor to study interactions between the HCV core protein and host cell factors within this specific region.

3.CLINICAL EFFICACY OF PRODUCT

• Research Tool Efficacy: Its "efficacy" is defined by its ability to specifically detect T-cell or antibody responses directed against this precise region of the HCV core protein, providing fine-mapping data on immune recognition.

• Immune Correlate Studies: Strong and broad T-cell responses against the HCV core protein, including potentially to epitopes like (107-114), have been associated with spontaneous viral clearance in acute infection and with favorable responses to interferon-based therapy in chronic infection. This peptide allows researchers to dissect these responses at an epitope level.

• Diagnostic Relevance: Antibodies against the HCV core protein are among the first to appear during infection and are the basis for many HCV diagnostic immunoassays. Research using peptides like (107-114) helps map immunodominant B-cell epitopes, which can inform the design of improved serological tests for early detection or differentiation of infection stages.

• Vaccine Context: While no prophylactic HCV vaccine exists, therapeutic vaccine candidates aim to induce robust T-cell responses. Defining conserved epitopes, such as those in the core protein, is a key strategy. This peptide contributes to that epitope identification and validation process.




4.DELIVERY & SHIPPING


We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods 
Main Method: International Air Freight


We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.