HCV NS4A Protein (21-34) (JT strain) CAS NO.176260-88-1

HCV NS4A Protein (21-34) (JT strain) is a high-purity synthetic peptide fragment corresponding to residues 21-34 of the Hepatitis C virus NS4A protein from the JT strain. This 14-amino acid peptide represents a critical functional domain involved in HCV replication complex formation and NS3 protease cofactor activity. Manufactured under stringent quality controls with HPLC-verified purity and comprehensive analytical documentation, this product provides researchers with a specialized tool for studying HCV viral replication, protein-protein interactions, and antiviral drug discovery. The JT strain-specific sequence enables precise investigation of strain-dependent variations in HCV biology and therapeutic targeting.

Send Email

Download

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	HCV NS4A Protein (21-34) (JT strain)
CAS NO.	176260-88-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C63H116N20O17
Molecular Weight	1425.75g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in DMSO, PBS (pH 7-8), or buffer solutions containing organic solvents.
Endotoxin	< 1.0 EU/mg
Biological Activity	Functional fragments of the HCV NS4A protein; involved in the assembly and membrane anchoring of the viral replication complex, and can be used to study NS4A-NS3 protease interactions, viral replication mechanisms, and antiviral drug screening.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

HCV NS4A Protein (21-34) (JT strain) functions as a key component of the HCV replication complex, serving as an essential cofactor for the NS3 serine protease. This peptide region facilitates proper folding and membrane localization of the NS3-NS4A complex, enhancing protease activity for viral polyprotein processing. The fragment contains critical residues that mediate interaction with NS3, promoting the formation of active protease complexes necessary for cleaving downstream viral proteins. Additionally, this region contributes to membrane association of the replication complex, creating a platform for viral RNA synthesis. The peptide can competitively inhibit NS3-NS4A interaction, making it valuable for studying protease function and screening for allosteric inhibitors.

2.PRODUCT INDICATIONS

HCV Replication Research: Investigation of viral replication complex assembly and function

Protein-Protein Interaction Studies: Analysis of NS3-NS4A complex formation and stability

Antiviral Drug Discovery: Screening for NS3 protease inhibitors and allosteric modulators

Structural Biology: Crystallography and NMR studies of NS4A functional domains

Strain-Specific Research: Comparative studies of different HCV strain variations

Virology Education: Teaching and research tool for HCV molecular biology

3.CLINICAL EFFICACY OF PRODUCT

Sequence Accuracy: Verified 14-amino acid sequence specific to HCV JT strain NS4A (21-34)

Biological Relevance: Maintains structural and functional properties of the native NS4A domain

Research Reproducibility: Consistent performance in protease activity and binding assays

Quality Documentation: Certificate of Analysis provided with purity, mass spec, and analytical data

Technical Support: Access to strain-specific application guidance for HCV research

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.