[D-Arg6,Asn10]-MCH (6-16) amide (human, mouse, rat) CAS NO.440635-61-0

[D-Arg⁶, Asn¹⁰]-MCH (6-16) amide (human, mouse, rat) is a high-purity, species-specific modified peptide designed for advanced research in neuroendocrine regulation and metabolic studies. This synthetic peptide features strategic amino acid modifications—including a D-arginine at position 6 and an asparagine at position 10—along with C-terminal amidation, enhancing its metabolic stability and receptor selectivity. Available for human, mouse, and rat models, it serves as a potent and selective agonist/antagonist tool for studying melanin-concentrating hormone (MCH) receptor signaling, energy homeostasis, and appetite regulation across species. Manufactured under stringent quality controls with HPLC-verified purity and comprehensive analytical validation, it ensures reliable and reproducible performance in both in vitro and in vivo applications.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[D-Arg6,Asn10]-MCH (6-16) amide (human, mouse, rat)
CAS NO.	440635-61-0
Appearance	White to off-white lyophilized powder
Molecular Formula	C60H100N22O14S3
Molecular Weight	1449.8 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, acetic acid (0.1%), DMSO
Endotoxin	< 1.0 EU/mg
Biological Activity	A modified melanin-gatherinating hormone fragment; D-arginine at position 6, asparagine at position 10, C-terminal amidation. It may possess enhanced enzyme stability or alter receptor selectivity, and could be used for MCH receptor pharmacology, energy balance, and feeding behavior studies.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

[D-Arg⁶, Asn¹⁰]-MCH (6-16) amide functions as a modified melanin-concentrating hormone (MCH) receptor ligand with enhanced pharmacological properties. The D-arginine substitution at position 6 significantly improves peptide stability against enzymatic degradation, while the Asn¹⁰ modification fine-tunes receptor binding affinity and selectivity. This peptide selectively binds to MCH receptor subtypes (MCHR1 and MCHR2), activating G-protein coupled signaling pathways that modulate intracellular cAMP levels, calcium mobilization, and downstream effector systems. Its action influences key neuroendocrine circuits involved in appetite suppression, energy expenditure, stress responses, and pigment aggregation mechanisms, providing a precise tool for dissecting MCH-mediated physiological and behavioral regulation.

2.PRODUCT INDICATIONS

Metabolic Disorder Research: Investigation of appetite regulation, energy balance, and obesity mechanisms in human and rodent models

Neuroendocrine Studies: Exploration of MCH signaling in stress, anxiety, depression, and sleep-wake cycles

Receptor Pharmacology: Characterization of MCH receptor subtype specificity, binding kinetics, and signal transduction

Drug Discovery: Screening and development of novel MCH receptor modulators for metabolic and psychiatric disorders

Comparative Physiology: Cross-species studies of MCH system evolution and function in human, mouse, and rat models

Behavioral Neuroscience: Assessment of MCH effects on feeding behavior, motivation, and reward processing

3.CLINICAL EFFICACY OF PRODUCT

Enhanced Stability: D-amino acid incorporation extends in vivo half-life and resistance to protease degradation

High Purity: ≥95% by RP-HPLC with mass spectrometry confirmation of modifications and amidation

Species-Specific Validity: Available in human, mouse, and rat sequences for translationally relevant research

Reproducible Bioactivity: Validated in receptor binding, cAMP inhibition, and feeding behavior assays

Quality Assurance: Produced under GLP-like conditions with low endotoxin levels for in vitro and preclinical use

Documentation Support: Comprehensive Certificate of Analysis including sequence verification, purity data, and functional assay references

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.