Hepatitus B Virus Pre-S Region (120-145) CAS NO.104504-34-9

Hepatitis B Virus Pre-S Region (120-145) is a high-purity synthetic peptide representing a critical functional domain of the HBV Pre-S envelope protein. This 26-amino acid peptide plays a key role in viral attachment, host cell interaction, and immune recognition, making it an essential research tool for studying HBV pathogenesis, vaccine development, and therapeutic discovery. Manufactured under stringent quality controls with HPLC-verified purity and comprehensive analytical documentation, this peptide enables advanced investigation into HBV entry mechanisms, neutralizing antibody responses, and diagnostic assay design.

Send Email

Download

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Hepatitus B Virus Pre-S Region (120-145)
CAS NO.	104504-34-9
Appearance	White to off-white lyophilized powder
Molecular Formula	C135H199N39O38S
Molecular Weight	3008.4g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in DMSO, PBS (pH 7-8), or an aqueous solution containing an organic solvent.
Endotoxin	< 1.0 EU/mg
Biological Activity	Immunoreactive peptides from the HBV Pre-S antigen region; capable of inducing B cell and T cell immune responses, used for HBV vaccine development, antibody screening, immune detection, and immune mechanism research.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The HBV Pre-S Region (120-145) mediates viral attachment and entry by interacting with specific host cell receptors, including the sodium taurocholate co-transporting polypeptide (NTCP). This peptide region is essential for viral docking, membrane fusion, and subsequent infection of hepatocytes. It also contains key epitopes recognized by neutralizing antibodies, making it a target for immune-mediated viral clearance. Additionally, the Pre-S region may modulate host immune responses, influencing both innate and adaptive immunity during HBV infection. The peptide can be used to competitively inhibit viral entry, map antibody-binding sites, and study receptor-ligand interactions in vitro and in vivo.

2.PRODUCT INDICATIONS

Viral Entry Research: Investigation of HBV attachment, receptor binding, and fusion mechanisms

Vaccine Development: Design and evaluation of Pre-S-targeted prophylactic and therapeutic vaccines

Therapeutic Antibody Screening: Identification and characterization of neutralizing antibodies

Diagnostic Assay Development: Development of serological tests for HBV detection and monitoring

Host-Pathogen Interaction Studies: Analysis of HBV interactions with hepatocytes and immune cells

Antiviral Drug Discovery: Screening for entry inhibitors and novel antiviral compounds

3.CLINICAL EFFICACY OF PRODUCT

Biological Relevance: Maintains structural and functional properties critical for HBV research

Sequence Accuracy: Verified 26-amino acid sequence corresponding to HBV Pre-S region (120-145)

Research Reproducibility: Consistent performance in binding, neutralization, and immunization assays

Low Endotoxin:<1.0 eu="">

Quality Documentation: Certificate of Analysis provided with purity, mass spec, and functional data

Technical Support: Access to application guidance for HBV virology and immunology research

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.