Histatin-8 [Hemagglutination – Inhibiting Peptide (HIP)] CAS NO.127637-03-0

Histatin-8 [Hemagglutination-Inhibiting Peptide (HIP)] is a high-purity synthetic peptide derived from the human salivary histatin family, known for its potent hemagglutination-inhibiting, antifungal, and antimicrobial activities. This multifunctional peptide plays a critical role in innate immune defense, particularly in oral and mucosal immunity. Manufactured under stringent quality controls with ≥95% HPLC-verified purity and comprehensive analytical documentation, it provides researchers with a reliable tool for studying host-pathogen interactions, microbial adhesion, and therapeutic applications in infectious diseases. Its ability to inhibit hemagglutination makes it a valuable candidate for antiviral and antibacterial research.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Histatin-8 [Hemagglutination – Inhibiting Peptide (HIP)]
CAS NO.	127637-03-0
Appearance	White to off-white lyophilized powder
Molecular Formula	C70H99N25O17
Molecular Weight	1562.73g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, PBS (pH 7-8), or dilute acetic acid.
Endotoxin	< 1.0 EU/mg
Biological Activity	Histone family members possess antifungal and antimicrobial activities and can inhibit erythrocyte aggregation; they also participate in oral immune defense.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Histatin-8 exerts its biological effects through multiple mechanisms: (1) Hemagglutination Inhibition – by competitively binding to viral or bacterial hemagglutinin proteins, blocking their interaction with host cell surface receptors (e.g., sialic acid residues), thereby preventing agglutination and cellular entry; (2) Antifungal Activity – disruption of fungal cell membrane integrity via electrostatic interactions and pore formation, leading to ion leakage and cell death; (3) Antimicrobial Action – targeting microbial membranes and interfering with intracellular processes, such as protein synthesis and enzyme activity; and (4) Immunomodulation – influencing inflammatory responses and immune cell recruitment. Its amphipathic structure and cationic nature enable broad-spectrum activity against pathogens.

2.PRODUCT INDICATIONS

Infectious Disease Research: Study of microbial adhesion, invasion, and host-pathogen interactions

Antiviral Studies: Investigation of hemagglutination inhibition and viral entry blockade

Antifungal & Antimicrobial Development: Screening and design of novel peptide-based therapeutics

Oral Immunology: Research on salivary defense mechanisms and mucosal immunity

Diagnostic Assay Development: Use in hemagglutination inhibition tests (HAI) for pathogen detection

Biomaterial Coating: Application in antimicrobial surface coatings for medical devices

3.CLINICAL EFFICACY OF PRODUCT

Broad-Spectrum Efficacy: Demonstrated activity against bacteria, fungi, and viruses in preclinical models

Research Reproducibility: Consistent performance across biochemical, cellular, and functional studies

Low Endotoxin:<1.0 eu="">

Quality Documentation: Certificate of Analysis (CoA) provided with purity, stability, and functional data

Scalable Supply: Available from research to preclinical quantities with custom modification options

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.