LHRH-Ⅲ, lamprey CAS NO.147859-97-0

LHRH-Ⅲ, lamprey is a high-purity synthetic decapeptide corresponding to the third isoform of lamprey gonadotropin-releasing hormone. This evolutionarily conserved neuropeptide plays a crucial role in regulating reproductive functions in jawless vertebrates, making it a valuable tool for comparative endocrinology, evolutionary biology, and neuroendocrine research. Manufactured under stringent quality controls with HPLC-verified purity and comprehensive analytical documentation, this peptide provides researchers with a species-specific tool to study the evolution of hypothalamic-pituitary-gonadal axis regulation, neuropeptide signaling, and vertebrate reproductive physiology.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	LHRH-Ⅲ, lamprey
CAS NO.	147859-97-0
Appearance	White to off-white lyophilized powder
Molecular Formula	C59H75N18O14
Molecular Weight	1259.4 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute acetic acid, DMSO
Endotoxin	< 1.0 EU/mg
Biological Activity	Lamprey gonadotropin-releasing hormone III; involved in regulating reproductive axis function, and can be used in comparative endocrinology, reproductive physiology, and evolutionary research.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

LHRH-Ⅲ, lamprey functions as a neuroendocrine peptide that binds to specific G-protein coupled gonadotropin-releasing hormone receptors in the lamprey pituitary. This binding activates phospholipase C-mediated signaling pathways, leading to increased intracellular calcium levels and protein kinase C activation. The downstream effects stimulate the synthesis and release of gonadotropins, which regulate gonadal development, steroidogenesis, and reproductive behaviors. The peptide exhibits distinct receptor-binding properties compared to mammalian GnRH isoforms, providing insights into the evolutionary adaptation of neuroendocrine systems. Its structural features, including conserved N-terminal pyroglutamate and C-terminal amidation, contribute to receptor recognition and metabolic stability in aquatic environments.

2.PRODUCT INDICATIONS

Comparative Endocrinology: Study of GnRH system evolution across vertebrate lineages

Reproductive Biology: Investigation of lamprey reproductive physiology and spawning regulation

Evolutionary Neuroscience: Research on neuropeptide system conservation and diversification

Neuroendocrine Research: Analysis of hypothalamic-pituitary-gonadal axis regulation in basal vertebrates

Conservation Physiology: Assessment of environmental impacts on lamprey reproduction

Peptide Evolution: Structural and functional studies of GnRH family diversification

3.CLINICAL EFFICACY OF PRODUCT

High Purity: ≥95% by RP-HPLC with mass spectrometry confirmation of lamprey-specific sequence

Species Authenticity: Verified amino acid sequence corresponding to native lamprey LHRH-Ⅲ

Biological Activity: Validated in receptor binding assays and physiological studies

Research Reproducibility: Consistent performance in comparative and functional assays

Quality Documentation: Certificate of Analysis provided with purity, mass spec, and analytical data

Technical Support: Access to application guidance for evolutionary and comparative research

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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