Luteinizing Hormone-Releasing Hormone, free acid, human; LH-RH, free acid, human
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Luteinizing Hormone-Releasing Hormone, free acid, human; LH-RH, free acid, human |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C58H81N17O16S |
| Molecular Weight | 1304.45g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, dilute acetic acid (0.1%), PBS (pH 7‑8) |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Gonadotropin-releasing hormone (GnRH) in its free acidic form; it binds to pituitary GnRH receptors, influencing the synthesis and release of luteinizing hormone and follicle-stimulating hormone, and regulating the reproductive axis. |
| Storage Conditions | Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
LH-RH, free acid functions as a key neuroendocrine regulator by binding to specific G-protein coupled GnRH receptors in the anterior pituitary. This binding activates phospholipase C-mediated signaling pathways, leading to increased intracellular calcium levels and protein kinase C activation. The downstream effects stimulate the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which subsequently regulate gonadal steroidogenesis, gametogenesis, and reproductive behaviors. The free acid C-terminus may influence receptor binding affinity, metabolic stability, and clearance kinetics compared to amidated forms, providing insights into structure-activity relationships and peptide metabolism. This form is particularly useful for studying the impact of C-terminal modifications on receptor activation and downstream signaling cascades.
2.PRODUCT INDICATIONS
3.CLINICAL EFFICACY OF PRODUCTStructural Authenticity: Verified free acid C-terminus (COOH) and native human sequence
Biological Relevance: Validated in receptor binding and functional assays
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
