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β-Lipotropin (61-69) CAS NO.72826-15-4

β-Lipotropin (61-69) (CAS 72826-15-4) is a synthetic nonapeptide fragment corresponding to residues 61-69 of the human β-Lipotropin (β-LPH) protein, with the sequence Asp-Lys-Arg-Tyr-Gly-Gly-Phe-Met-Thr. This specific sequence constitutes the core N-terminal region of β-Endorphin (β-EP, residues 61-91 of β-LPH), which is a potent endogenous opioid peptide.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	β-Lipotropin (61-69)
CAS NO.	72826-15-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C45H66N10O15S
Molecular Weight	1019.15g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute PBS (pH 7.0-7.4), 0.1% TFA aqueous solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	Endogenous 9-mer bioactive fragment of β-Lipotropin (β-LPH); a key peptide involved in lipid metabolism regulation, pituitary hormone secretion modulation and central nervous system signaling.
Storage Conditions	Store at -20°C to -80°C in a sealed, dry and light-protected container; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide fragment itself does not possess significant opioid receptor agonist activity. Full opioid activity requires the longer β-Endorphin sequence (e.g., 61-91 or 61-76). The mechanism of this fragment is primarily related to its role as a biosynthetic precursor and an antigenic determinant:

Precursor Fragment: It represents the initial segment generated upon cleavage of β-Lipotropin by prohormone convertases to produce β-Endorphin. It may serve as an intermediate in the stepwise processing of β-LPH.

Antigenic Core: The sequence contains the N-terminal "message" domain (Tyr-Gly-Gly-Phe) common to all endogenous opioid peptides, but lacks the critical C-terminal "address" domain required for high-affinity receptor binding. Therefore, it can bind to some antibodies against β-Endorphin but cannot effectively activate μ-opioid (MOP), δ-opioid (DOP), or κ-opioid (KOP) receptors.

2.PRODUCT INDICATIONS

Antibody Production & Specificity Testing: Conjugating the peptide to a carrier protein to generate antibodies specific to the N-terminal region of β-Endorphin. It is also used to test the specificity of commercial anti-β-Endorphin antibodies in competitive immunoassays, distinguishing antibodies that recognize the N-terminus.
Metabolic Pathway Studies: Investigating the enzymatic processing of β-Lipotropin into β-Endorphin and smaller fragments (e.g., α-Endorphin, γ-Endorphin) by serving as a substrate or reference standard in in vitrocleavage assays.
Chromatographic & Mass Spectrometry Standards: Acting as a defined reference compound in high-performance liquid chromatography (HPLC) or mass spectrometry (MS) to identify and quantify β-Endorphin-related peptides in tissue extracts or biological fluids.

3.CLINICAL EFFICACY OF PRODUCT

Research & Diagnostic Tool Efficacy: Its efficacy lies in its specific utility as an immunological and biochemical tool. It is highly effective for generating N-terminally specific antibodies and for studying the precise cleavage events in β-Endorphin biosynthesis.
Biological Context: The full peptide from which it is derived, β-Endorphin, is a clinically significant endogenous opioid with roles in pain modulation, stress response, and reward. Dysregulation of the POMC/β-Endorphin system is implicated in conditions like chronic pain, addiction, and depression.
Diagnostic Development: Antibodies characterized using this fragment contribute to the development of research immunoassays (RIAs, ELISAs) that measure β-Endorphin or its precursors.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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