VA – β – MSH, Lipotropin – γ, Proopiomelanocortin – derived

VA-β-MSH, Lipotropin-γ, Proopiomelanocortin-derived is a research-grade peptide product containing two bioactive fragments of the proopiomelanocortin (POMC) precursor. The β-MSH component has a CAS number of 17908-57-5, a molecular formula of C₁₁₈H₁₇₄N₃₄O₃₁S, and a molecular weight of 2666.95 g/mol. The γ-Lipotropin component has a CAS number of 17908-58-6, a molecular formula of C₂₆₅H₄₁₁N₇₁O₇₅S, and a molecular weight of 5941.70 g/mol. Manufactured to ≥98% purity via RP-HPLC, this product is ideal for studying melanocortin receptor signaling, lipid metabolism, and neuroendocrine pathways.

Send Email

Download

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	VA-β-MSH, Lipotropin-γ, Proopiomelanocortin-derived Peptide
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C126H188N36O37S
Molecular Weight	2831.19g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥10 mg/mL), dilute acetic acid, or 0.1M HCl; sparingly soluble in ethanol
Endotoxin	< 1.0 EU/mg
Biological Activity	β-MSH: Potent agonist of melanocortin receptors (MC1R, MC3R, MC4R, MC5R), induces melanin synthesis and pigmentation, regulates energy homeostasis and anti-inflammatory responses. γ-Lipotropin: Stimulates lipolysis in adipose tissue; precursor to β-endorphin and other bioactive peptides, exhibits weak opioid activity.
Storage Conditions	Store at -20°C to -80°C in a desiccated environment. Avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

VA-β-MSH: Acts as a potent agonist at melanocortin receptors (MC1R, MC3R, MC4R, MC5R). It binds to MC1R on melanocytes to stimulate tyrosinase activity and melanin synthesis, and interacts with MC3R/MC4R in the hypothalamus to regulate energy balance and suppress inflammation.

γ-Lipotropin: Promotes lipolysis in adipocytes by activating hormone-sensitive lipase, releasing free fatty acids into the bloodstream. It also serves as a precursor to β-endorphin, exerting weak opioid effects on the central nervous system.

2.PRODUCT INDICATIONS

Skin pigmentation disorders and photoprotection mechanisms

Obesity and metabolic syndrome pathways

Neuroendocrine regulation of appetite and energy homeostasis

Anti-inflammatory and immunomodulatory responses

Opioid peptide biosynthesis and pain signaling

3.CLINICAL EFFICACY OF PRODUCT

VA-β-MSH: Effective in inducing skin darkening for photoprotection in UV-exposed skin, and reducing inflammation in models of psoriasis and atopic dermatitis.γ-Lipotropin: Shows potential in mobilizing stored fat in animal models of obesity, with implications for lipid disorder therapies.Both peptides are being investigated for their role in regulating stress responses and mood disorders via the POMC pathway.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.