MAGE-3 Antigen (167-176), human CAS NO.178243-46-4

MAGE-3 Antigen (167-176), human is a high-purity synthetic decapeptide corresponding to the HLA-A0101-restricted cytotoxic T lymphocyte (CTL) epitope of human melanoma-associated antigen 3 (MAGE-A3). This 10-amino acid peptide (ALVVPGPRAL) is derived from the MAGE-A3 tumor antigen and serves as a key target for cancer immunotherapy research. Manufactured under stringent quality controls with HPLC-verified purity and comprehensive analytical documentation, this peptide provides researchers with a precise tool for studying tumor immunology, T cell activation, cancer vaccine development, and adoptive T cell therapy. Its HLA-A0101 restriction makes it particularly valuable for studies involving this human leukocyte antigen haplotype.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	MAGE-3 Antigen (167-176), human
CAS NO.	178243-46-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C53H80N12O16S
Molecular Weight	1173.36g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in DMSO, PBS (pH 7-8), or physiological saline.
Endotoxin	< 1.0 EU/mg
Biological Activity	The HLA-A*0101-restricted CTL epitope of human melanoma-associated antigen MAGE-3 can induce a specific CD8⁺ T cell immune response, making it suitable for research in tumor immunology, vaccines, and T cell therapy.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

MAGE-3 Antigen (167-176) functions as a tumor-associated antigen peptide that is processed and presented by antigen-presenting cells (APCs) via the MHC class I pathway. Dendritic cells and other APCs internalize and process the peptide, loading it onto HLA-A0101 molecules for presentation on the cell surface. This peptide-MHC complex is recognized by CD8⁺ cytotoxic T lymphocytes (CTLs) bearing T cell receptors (TCRs) specific for this epitope. The TCR engagement triggers T cell activation, proliferation, and differentiation into effector CTLs. These activated CTLs can then recognize and lyse tumor cells expressing the MAGE-A3 antigen, leading to tumor cell death. The peptide's specific sequence (ALVVPGPRAL) contains anchor residues that ensure high-affinity binding to HLA-A0101, making it an immunodominant epitope for T cell recognition.

2.PRODUCT INDICATIONS

Cancer Immunotherapy Research: Development and evaluation of MAGE-A3-targeted cancer vaccines

T Cell Activation Studies: Investigation of CTL activation, proliferation, and effector function

Adoptive T Cell Therapy: Generation and expansion of MAGE-A3-specific T cells for therapeutic applications

Immune Monitoring: Detection and quantification of MAGE-A3-specific T cell responses (ELISPOT, tetramer staining)

TCR Screening: Identification and validation of T cell receptors targeting MAGE-A3

Tumor Immunology: Study of antigen presentation, immune evasion, and tumor microenvironment

3.CLINICAL EFFICACY OF PRODUCT

High Purity: ≥95% by RP-HPLC with mass spectrometry confirmation of sequence and structure

Sequence Authenticity: Verified ALVVPGPRAL sequence corresponding to MAGE-A3 167-176

Biological Activity: Validated in T cell activation assays, MHC multimer staining, and functional studies

HLA-A0101 Binding: Confirmed high-affinity binding to HLA-A0101 molecules

Research Reproducibility: Consistent performance in immunological assays and T cell studies

Low Endotoxin:<1.0 eu="">

Quality Documentation: Certificate of Analysis provided with purity, mass spec, and analytical data

Technical Support: Access to application guidance for cancer immunology and T cell research

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.