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MART-1 (26-35) (human) CAS NO.156251-01-3

MART-1 (26-35) (human) is a synthetic decapeptide corresponding to residues 26-35 of the human melanoma antigen recognized by T-cells (MART-1). With CAS NO. 156251-01-3, it is a high-purity, well-defined research tool primarily used in immunology and oncology to study T-cell mediated immune responses against melanoma and other cancers.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	MART-1 (26-35) (human)
CAS NO.	156251-01-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C42H74N10O14
Molecular Weight	943.12g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, 0.1 M acetic acid, or DMSO at a concentration ≥ 1 mg/mL.
Endotoxin	< 1.0 EU/mg
Biological Activity	Recognized by HLA-A2-restricted cytotoxic T lymphocytes (CTLs) specific to MART-1.
Storage Conditions	Store long-term at -20°C to -80°C; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide is a native HLA-A*02:01-restricted epitope derived from the melanocyte differentiation antigen MART-1/Melan-A. When presented by antigen-presenting cells (APCs), it effectively activates antigen-specific cytotoxic T-lymphocytes (CTLs). These activated CTLs then recognize and eliminate tumor cells expressing the endogenous MART-1 protein, providing a specific target for adaptive anticancer immunity.

2.PRODUCT INDICATIONS

This peptide is indicated for use in scientific research applications, including: in vitro T-cell stimulation and expansion, immune monitoring assays, development and evaluation of peptide-based cancer vaccines, assessment of adoptive T-cell therapy efficacy, and as a critical reagent for studying antigen-specific immune responses in melanoma and vitiligo research.

3.CLINICAL EFFICACY OF PRODUCT

As a research-grade reagent, MART-1 (26-35) is a cornerstone antigen in numerous clinical investigations. Studies have demonstrated its ability to consistently induce robust MART-1-specific T-cell responses in vitro and in vivo. It has been widely used in clinical trials for melanoma vaccines and adoptive T-cell transfer therapies, showing safety and immunogenicity, though therapeutic efficacy can vary based on the treatment modality and patient factors.

4.DELIVERY & SHIPPING

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