Mastoparan CAS NO.72093-21-1

Mastoparan is a high-purity synthetic tetradecapeptide derived from wasp venom, characterized by its amphipathic α-helical structure and potent biological activities. This 14-amino acid peptide (INLKALAALAKKIL-NH₂, C-terminal amidated) is manufactured under stringent quality controls with HPLC-verified purity and comprehensive analytical documentation. Mastoparan serves as a versatile research tool for studying G-protein signaling, membrane permeability, antimicrobial mechanisms, and secretory processes. Its ability to directly activate G proteins and modulate membrane dynamics makes it valuable for cell signaling research, pharmacology studies, and antimicrobial mechanism investigations.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Mastoparan
CAS NO.	72093-21-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C70H131N19O15
Molecular Weight	1478.9g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, PBS (pH 7-8), DMSO
Endotoxin	< 1.0 EU/mg
Biological Activity	A fourteen-peptide derived from wasp venom; possessing multiple biological activities including G protein activation, membrane permeability regulation, antibacterial activity, and secretion promotion, it is used in signal transduction, cell biology, and drug research.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Mastoparan functions primarily through its amphipathic α-helical structure that enables interaction with cell membranes and G-protein coupled receptors (GPCRs). The peptide inserts into lipid bilayers, forming transient pores and increasing membrane permeability. More significantly, Mastoparan directly activates heterotrimeric G proteins (particularly Gi/Go subtypes) by mimicking the intracellular loop of activated GPCRs, leading to GDP-GTP exchange and downstream signaling activation. This G-protein activation occurs independently of receptor engagement, making it a valuable tool for studying G-protein signaling pathways. Additionally, Mastoparan can stimulate phospholipase C activity, modulate ion channels, and induce calcium influx, contributing to its diverse biological effects including mast cell degranulation, hormone secretion, and antimicrobial activity through membrane disruption.

2.PRODUCT INDICATIONS

G-Protein Signaling Research: Study of Gi/Go protein activation, GTPase activity, and downstream signaling pathways

Membrane Permeability Studies: Investigation of peptide-membrane interactions and pore formation mechanisms

Antimicrobial Research: Evaluation of antimicrobial mechanisms against Gram-positive and Gram-negative bacteria

Secretory Process Studies: Research on mast cell degranulation, hormone release, and exocytosis mechanisms

Cell Signaling Pharmacology: Screening for G-protein modulators and signal transduction pathway analysis

Comparative Peptide Studies: Structure-activity relationship research of amphipathic peptides

3.CLINICAL EFFICACY OF PRODUCT

High Purity: ≥95% by RP-HPLC with mass spectrometry confirmation of sequence and structure

Sequence Authenticity: Verified INLKALAALAKKIL-NH₂ sequence with C-terminal amidation

Biological Activity: Validated in G-protein activation assays, membrane permeability studies, and antimicrobial tests

Research Reproducibility: Consistent performance in signaling assays and functional studies

Low Endotoxin:<1.0 eu="">

Quality Documentation: Certificate of Analysis provided with purity, mass spec, and analytical data

Technical Support: Access to application guidance for G-protein signaling and membrane biology research

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.