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Mas17

But17 is a potent synthetic peptide inhibitor specifically designed to target and inhibit the interaction between the chaperone protein 14-3-3 and its client proteins. This high-purity, research-grade compound serves as a crucial tool molecule in molecular biology and drug discovery, enabling the precise dissection of disease-related signaling pathways where 14-3-3 protein complexes play a central regulatory role.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Mas17
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C70H132N20O15
Molecular Weight	1493.96g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, 0.1 M acetic acid, or DMSO at ≥ 1 mg/mL concentration
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent agonist of the Mas receptor; activates downstream signaling pathways
Storage Conditions	Store long-term at -20°C to -80°C; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

But17 functions by competitively binding to the amphipathic groove of 14-3-3 proteins. This binding effectively disrupts the formation of functional 14-3-3/client protein complexes. By preventing this critical protein-protein interaction (PPI), But17 modulates downstream signaling cascades, leading to altered cellular processes such as apoptosis, cell cycle progression, and metabolism, which are often dysregulated in diseases like cancer and neurodegeneration.

2.PRODUCT INDICATIONS

This product is indicated for in vitro and cellular research applications. Key uses include: studying the biological functions of 14-3-3 proteins, validating 14-3-3/client interactions as therapeutic targets, screening for downstream effects in oncology and neurology research, and serving as a positive control in assays designed to identify novel 14-3-3 inhibitors.

3.CLINICAL EFFICACY OF PRODUCT

But17 is a preclinical research tool and is not used in clinical therapy. However, its demonstrated efficacy in disrupting specific 14-3-3 interactions in experimental models validates the 14-3-3 interface as a druggable target. Research utilizing But17 has provided critical proof-of-concept evidence, supporting the development of novel therapeutic strategies aimed at modulating PPIs for conditions like cancer, where 14-3-3 proteins are often overexpressed and contribute to pathogenesis.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.