Mas8
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Mas8 |
| CAS NO. | \ |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C70H131N21O15 |
| Molecular Weight | 1506.96g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water (≥10 mg/mL), dilute acetic acid, or 0.01M PBS |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Potent and selective agonist for the MRGPRX8 receptor, mediating analgesic and anti-inflammatory effects by modulating peripheral sensory neuron signaling. Validated for pain research and inflammation pathway studies. |
| Storage Conditions | 20°C to -80°C in a desiccated environment, avoiding repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Mas8 Peptide acts as a potent, selective agonist for the MRGPRX8 receptor, which is primarily expressed on peripheral sensory neurons. Upon binding, it triggers intracellular signaling cascades that modulate neuron excitability, leading to reduced pain perception and suppression of pro-inflammatory cytokine release. This mechanism enables targeted investigation of pain pathways without central nervous system side effects, making it valuable for analgesic drug development.
2.PRODUCT INDICATIONS
Peripheral pain signaling and nociceptor activation
Anti-inflammatory pathway modulation
MRGPRX8 receptor pharmacology
Preclinical development of novel analgesics
Sensory neuron function and neuroinflammation
3.CLINICAL EFFICACY OF PRODUCT
Potent analgesic effects in animal models of inflammatory and neuropathic pain
Significant reduction in pro-inflammatory markers (e.g., TNF-α, IL-6) in peripheral tissues
High selectivity for MRGPRX8, minimizing off-target effects
Potential as a lead compound for next-generation pain therapies with reduced CNS-related side effects
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
