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MBP (68-82), gulinea pig

MBP (68-82), guinea pig is a synthetic peptide fragment corresponding to amino acid residues 68-82 of the guinea pig Myelin Basic Protein (MBP). This highly purified antigenic peptide is a critical research tool specifically designed for immunological studies, serving as a key autoantigen in the experimental autoimmune encephalomyelitis (EAE) model, which mimics aspects of human multiple sclerosis (MS).

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	MBP (68-82)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C71H113N23O28
Molecular Weight	1736.8g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (pH 7.0-8.0), 0.1 M acetic acid, or DMSO at a concentration ≥ 1 mg/mL
Endotoxin	< 1.0 EU/mg
Biological Activity	A key immunogenic epitope of myelin basic protein; induces experimental autoimmune encephalomyelitis (EAE) in susceptible rodent models
Storage Conditions	Store long-term at -20°C to -80°C in a sealed container with desiccant.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

In research settings, this peptide acts as a potent encephalitogenic epitope. When administered with an appropriate adjuvant to susceptible guinea pigs, it is presented by Major Histocompatibility Complex (MHC) class II molecules on antigen-presenting cells. This presentation activates myelin-reactive CD4+ T helper cells (specifically Th1 and Th17 subsets), initiating a cascade of inflammatory responses that lead to the targeted demyelination of central nervous system neurons, thereby inducing the EAE disease state.

2.PRODUCT INDICATIONS

This product is indicated exclusively for preclinical research applications. Its primary use is to induce and study EAE in guinea pigs, making it essential for: investigating the immunopathogenesis of demyelinating diseases like MS, evaluating the efficacy and mechanisms of potential therapeutic agents for neuroinflammation, and studying T-cell epitope mapping and autoimmune response mechanisms.

3.CLINICAL EFFICACY OF PRODUCT

As a research-grade reagent, MBP (68-82), guinea pig is not used in human clinical therapy. Its efficacy is defined by its reliable and consistent ability to induce EAE in the established guinea pig model. This model's high predictability has been instrumental in validating the autoimmune basis of MS and remains a gold standard for the preclinical screening and development of numerous immunomodulatory and immunosuppressive therapies for demyelinating disorders.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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