MBP (1 – 11), mouse CAS NO.125366-42-9

MBP (1-11), mouse (CAS NO. 125366-42-9) is a synthetic peptide antigen representing the N-terminal epitope (amino acids 1-11) of mouse Myelin Basic Protein (MBP). This high-purity, research-grade peptide is a fundamental tool in neuroimmunology, specifically designed to induce and study experimental autoimmune encephalomyelitis (EAE) in susceptible mouse strains, serving as a key model for human multiple sclerosis (MS).

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	MBP (1-11)
CAS NO.	125366-42-9
Appearance	White to off-white lyophilized powder
Molecular Formula	C53H95N21O18
Molecular Weight	1314.48g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute hydrochloric acid, or neutral/weakly basic buffers
Endotoxin	≤50 EU/mg
Biological Activity	Major encephalitogenic epitope of myelin basic protein (MBP), capable of inducing experimental autoimmune encephalomyelitis (EAE) in susceptible mice.
Storage Conditions	Store at -20°C in a sealed container; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide functions as a dominant encephalitogenic epitope in H-2u mice (e.g., PL/J and B10.PL strains). Upon immunization with an adjuvant, it is processed and presented by MHC Class II (I-Au) molecules on antigen-presenting cells. This presentation potently activates autoreactive CD4+ T cells, primarily of the Th1 phenotype, which migrate to the central nervous system. There, they initiate a inflammatory cascade involving cytokines, chemokines, and macrophages, leading to targeted demyelination of nerve fibers and the clinical manifestations of EAE.

2.PRODUCT INDICATIONS

This product is indicated for preclinical biomedical research. Its primary application is the induction of the EAE model in mice to investigate the pathogenesis of autoimmune demyelinating diseases. It is also used for: studying antigen-specific T cell activation and tolerance, evaluating potential therapies for MS and neuroinflammation, and as a critical reagent in immunological assays to track and characterize autoreactive T cell responses.

3.CLINICAL EFFICACY OF PRODUCT

MBP (1-11), mouse is a research tool and not a clinical therapeutic. Its efficacy is defined by its ability to reliably and reproducibly induce EAE with predictable kinetics and severity in appropriate mouse models. This high level of experimental efficacy has made it an indispensable standard for validating the autoimmune basis of MS and for the preclinical screening of countless immunomodulatory drugs and cellular therapies that have advanced to clinical trials.

4.DELIVERY & SHIPPING

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