[Ala4] – MBP (1 – 11)

[Ala4]-MBP (1-11) (CAS NO. 125366-42-9) is a high-purity synthetic peptide with the molecular formula C₄₉H₈₁N₂₁O₁₇ and a molecular weight of 1236.32 g/mol. It is a modified analog of the encephalitogenic myelin basic protein (MBP) (1-11) epitope, designed for advanced immunology and autoimmune disease research. This lyophilized white powder exhibits ≥95% purity (via RP-HPLC), excellent solubility in water and organic solvents, and reliable biological activity, making it a critical tool for scientists investigating the mechanisms of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). As a specialized research reagent, it is supplied with strict quality control to ensure consistency and reproducibility in preclinical studies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Ala4]-MBP (1-11)
CAS NO.	\
Appearance	White to off-white lyophilized powder
Molecular Formula	C₄₉H₈₁N₂₁O₁₇
Molecular Weight	1236.32g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, DMSO, or 1% acetic acid (recommended concentration: 1-10 mg/mL)
Endotoxin	< 1.0 EU/mg
Biological Activity	A synthetic analog of the encephalitogenic MBP (1-11) epitope, used in autoimmune disease research (e.g., EAE models). It retains MHC class II binding capacity and T-cell stimulatory activity.
Storage Conditions	Store at -20°C (desiccated, avoid repeated freeze-thaw cycles). Stable for 2 years when stored properly. Shipped at 4°C with ice packs.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

[Ala4]-MBP (1-11) functions as a modified antigenic peptide that binds to MHC class II molecules (e.g., I-Aⁿ in mice) and activates autoreactive CD4⁺ T cells.

Unlike the native MBP (1-11) sequence, the alanine substitution at position 4 alters its affinity for MHC complexes and T-cell receptors, enabling researchers to study the fine specificity of T-cell responses in autoimmune disease models.

This peptide induces a targeted immune response that mimics the pathological processes of multiple sclerosis, making it invaluable for dissecting the molecular basis of autoimmune neuroinflammation.

2.PRODUCT INDICATIONS

Research Use Only (RUO): For in vitro and in vivo studies of autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS) pathogenesis.

Ideal for investigating MHC-peptide-TCR interactions, T-cell activation, and the efficacy of potential immunotherapies.

Suitable for use in vaccine development and tolerance-induction experiments aimed at mitigating autoimmune responses.

3.CLINICAL EFFICACY OF PRODUCT

[Ala4]-MBP (1-11) is a preclinical research tool and has not been evaluated in human clinical trials.

In preclinical EAE models, it has demonstrated the ability to induce a reproducible autoimmune response, enabling researchers to test the efficacy of novel therapeutic agents, including peptide-based vaccines, monoclonal antibodies, and small-molecule inhibitors.

Its well-characterized activity profile supports its use as a gold-standard positive control in studies evaluating the potential of immunomodulatory drugs to suppress neuroinflammation.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.