TECHNICAL SPECIFICATIONS
Item
| Specification
|
|---|
Product Name
| [Arg91, Ala96] – MBP (87 – 99), human
|
CAS NO.
| / |
Appearance
| White to off-white lyophilized powder
|
Molecular Formula
| C72H112N22O17
|
Molecular Weight
| 1557.83g/mol |
Purity (RP-HPLC)
| ≥ 95.0% |
Solubility
| Soluble in water, PBS (pH 7-8), or an aqueous solution containing a small amount of DMSO.
|
| Endotoxin | < 1.0 EU/mg
|
Biological Activity
| Modified MBP autoimmune epitopes; Ile→Arg at position 91, Thr→Ala at position 96, may alter its immunogenicity, MHC binding, or T cell recognition properties, and can be used for multiple sclerosis models, autoimmune epitope optimization, and T cell research. |
Storage Conditions
| Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
|
Stock Location
| Stock in USA
|
MOQ
| 1g |
1.MECHANISM OF ACTION
[Arg91, Ala96] – MBP (87-99) functions as a modified autoantigen that interacts with MHC class II molecules on antigen-presenting cells, forming peptide-MHC complexes recognized by CD4⁺ T cell receptors. The Arg91 and Ala96 substitutions alter the peptide's binding affinity for MHC molecules and its interaction with T cell receptors, potentially modulating the activation threshold of autoreactive T cells. This modified epitope can induce differential T cell responses compared to the wild-type sequence, leading to altered cytokine profiles (Th1/Th2/Th17 polarization) and modified encephalitogenic potential. The peptide serves as a valuable tool for studying how specific amino acid changes in autoantigens influence immune recognition, T cell activation kinetics, and the development of autoimmune pathology in neuroinflammatory models.
2.PRODUCT INDICATIONS
Autoimmune Disease Research: Investigation of multiple sclerosis mechanisms and neuroinflammatory disorders using modified autoantigens
Epitope Optimization Studies: Analysis of how specific amino acid substitutions affect autoimmune epitope recognition and immunogenicity
T Cell Receptor Research: Study of TCR recognition specificity and activation thresholds using modified MBP epitopes
EAE Model Development: Induction and modulation of experimental autoimmune encephalomyelitis with engineered autoantigens
Immunotherapy Development: Screening and evaluation of antigen-specific tolerogenic or immunomodulatory strategies
Structure-Activity Relationship: Investigation of peptide-MHC and peptide-TCR interactions through systematic epitope modification
3.CLINICAL EFFICACY OF PRODUCT
Structural Precision: Verified VHFFKNRVAPRTP sequence with specified modifications
Biological Relevance: Validated in MHC binding assays, T cell activation studies, and EAE models
Research Utility: Enables precise investigation of epitope-immune system interactions with controlled modifications
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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