[Pyr4] – MBP (4 – 14) CAS NO.136132-68-8

[Pyr⁴]-MBP (4-14) (CAS NO. 120881-23-4) is a high-purity synthetic peptide with a molecular formula of C₅₉H₈₇N₂₁O₁₇ and a molecular weight of 1374.48 g/mol. It is a modified analog of the encephalitogenic myelin basic protein (MBP) (4-14) epitope, featuring a pyroglutamic acid substitution at position 4 to enhance stability and biological activity. This lyophilized white to off-white powder exhibits ≥95% purity (via RP-HPLC), excellent solubility in aqueous and organic solvents, and consistent performance in preclinical models, making it a critical tool for researchers investigating multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). As a specialized research reagent, it is manufactured under strict quality control to ensure reproducibility in studies of autoimmune neuroinflammation.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Pyr⁴]-MBP (4-14)
CAS NO.	136132-68-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C60H100N20O17
Molecular Weight	1391.61g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, 1% acetic acid, or DMSO (optimal concentration: 1-10 mg/mL)
Endotoxin	< 1.0 EU/mg
Biological Activity	A modified analog of the encephalitogenic MBP (4-14) epitope, which binds to MHC class II molecules (I-Aᵘ) and activates autoreactive T cells. It induces experimental autoimmune encephalomyelitis (EAE) in mice, serving as a key tool for studying multiple sclerosis (MS) pathogenesis.
Storage Conditions	Store at -20°C in a desiccated environment. Avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

[Pyr⁴]-MBP (4-14) acts as a high-affinity antigenic peptide that binds to MHC class II molecules (e.g., I-Aᵘ in mice) and activates autoreactive CD4⁺ T cells.

The pyroglutamic acid (Pyr) substitution at position 4 increases peptide stability and MHC binding affinity, leading to more potent and sustained T-cell activation compared to the native MBP (4-14) sequence.

This activation triggers a targeted immune response that mimics the pathological processes of MS, enabling researchers to dissect the molecular basis of autoimmune neuroinflammation and test potential therapies.

2.PRODUCT INDICATIONS

Research Use Only (RUO): For in vitro and in vivo studies of EAE and MS pathogenesis, including MHC-peptide-TCR interactions and T-cell-mediated neuroinflammation.

Ideal for evaluating the efficacy of immunotherapies, such as peptide-based vaccines, monoclonal antibodies, and small-molecule inhibitors, in preclinical models.

Suitable for tolerance-induction experiments and vaccine development aimed at mitigating autoimmune responses in the central nervous system.

3.CLINICAL EFFICACY OF PRODUCT

[Pyr⁴]-MBP (4-14) is a preclinical research tool and has not been evaluated in human clinical trials.

In murine EAE models, it consistently induces a reproducible autoimmune response, serving as a gold-standard positive control for testing novel anti-inflammatory and immunomodulatory agents.

Its well-characterized activity profile supports its use in validating the efficacy of potential MS therapies, including those targeting antigen presentation and T-cell activation.

4.DELIVERY & SHIPPING

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Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Main Method: International Air Freight

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