Biotin-Phosphorylated MBP (94 – 102)

Biotin-Phosphorylated MBP (94-102) is a synthetic, biotin-conjugated peptide corresponding to residues 94-102 of the myelin basic protein (MBP), featuring a site-specific phosphorylation modification. This high-purity, dual-functional reagent is designed for advanced molecular interaction studies, combining the biological activity of a phosphorylated MBP epitope with the strong binding affinity of biotin for streptavidin-based detection and isolation systems.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Biotin-Phosphorylated Myelin Basic Protein (94-102), also known as Biotin-pMBP (94-102)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C49H85N20O15S
Molecular Weight	1273.41g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute acetic acid, and neutral buffers (e.g., PBS pH 7.2-7.4).
Endotoxin	≤10 EU/mg
Biological Activity	A phosphorylated, biotinylated peptide epitope of MBP, used to study protein phosphorylation, kinase activity, and autoimmune responses.
Storage Conditions	Store at -20°C in a dry, sealed container; avoid repeated freeze-thaw cycles and exposure to moisture.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

As a phosphorylated antigenic epitope, this peptide mimics a post-translationally modified form of MBP. It serves as a specific ligand for antibodies, kinases, phosphatases, or other phospho-binding proteins (e.g., 14-3-3). The biotin tag enables its immobilization on streptavidin-coated surfaces (such as plates, beads, or biosensors), facilitating the capture, detection, and quantification of interacting biomolecules in highly controlled assays.

2.PRODUCT INDICATIONS

This specialized reagent is indicated for proteomics, signal transduction, and immunoassay research. Key applications include: studying kinase/phosphatase activity toward MBP, developing phospho-specific antibody assays, investigating protein-protein interactions involving phosphorylated MBP, performing pull-down assays to identify binding partners, and serving as a critical standard in phosphorylation-dependent diagnostic or screening platforms.

3.CLINICAL EFFICACY OF PRODUCT

Biotin-Phosphorylated MBP (94-102) is a research tool, not a therapeutic. Its value lies in its high specificity and utility in translational research. By enabling precise investigation of phosphorylation-dependent events in demyelinating diseases like multiple sclerosis (MS), it contributes to biomarker discovery, drug target validation, and diagnostic assay development—key steps toward clinically relevant innovations in neuroimmunology and personalized medicine.

4.DELIVERY & SHIPPING

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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Main Method: International Air Freight

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