MBP (74 – 85), guinea pig

MBP (74-85), guinea pig is a synthetic peptide fragment corresponding to amino acid residues 74-85 of the guinea pig Myelin Basic Protein (MBP). This high-purity, defined antigen is a cornerstone research tool in neuroimmunology, specifically recognized as a primary encephalitogenic epitope for inducing the classical Experimental Autoimmune Encephalomyelitis (EAE) model, which is fundamental for studying the immunopathogenesis of multiple sclerosis.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Myelin Basic Protein (74-85), guinea pig
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C56H94N20O23
Molecular Weight	1415.49 g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water, dilute acetic acid, and neutral buffers
Endotoxin	< 1.0 EU/mg
Biological Activity	A major encephalitogenic epitope of guinea pig myelin basic protein, capable of inducing experimental autoimmune encephalomyelitis (EAE) in guinea pigs and other susceptible rodents
Storage Conditions	Store at -20°C in a dry, sealed container; avoid repeated freeze-thaw cycles and exposure to moisture.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide acts as a dominant antigenic determinant. When administered with an adjuvant to susceptible guinea pigs, it is processed by antigen-presenting cells and presented in the context of Major Histocompatibility Complex (MHC) Class II molecules. This presentation potently activates autoreactive CD4+ T helper cells, triggering a cascade of pro-inflammatory cytokine release and cellular infiltration into the central nervous system.

2.PRODUCT INDICATIONS

This product is indicated for preclinical research in autoimmune and neurological disorders. Its primary application is the reliable induction of EAE in guinea pigs for: investigating the mechanisms of autoimmune demyelination, evaluating the efficacy and mode of action of potential therapeutic agents for multiple sclerosis, and studying fundamental processes of T-cell activation, epitope spreading, and immune tolerance in a controlled in vivo setting.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, MBP (74-85), guinea pig is not used in clinical treatment. Its efficacy is defined by its robust and reproducible capacity to induce EAE, making it a gold-standard tool for over half a century. This model has been instrumental in validating the autoimmune basis of MS and has served as the primary preclinical screening platform for the vast majority of immunomodulatory and immunosuppressive therapies currently approved for MS, directly linking its research use to clinical advancement.

4.DELIVERY & SHIPPING

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