MBP (1 – 17)
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | MBP (1-17) |
| CAS NO. | \ |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C79H135N27O26 |
| Molecular Weight | 1879.12g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, 1% acetic acid, or DMSO (optimal concentration: 1-10 mg/mL) |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | A synthetic fragment of myelin basic protein (MBP) that binds to MHC class II molecules and activates autoreactive CD4⁺ T cells. It is a potent inducer of experimental autoimmune encephalomyelitis (EAE) in animal models, serving as a key tool for studying multiple sclerosis (MS) pathogenesis. |
| Storage Conditions | Store at -20°C in a desiccated environment. Avoid repeated freeze-thaw cycles. Stable for 2 years under proper storage. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
MBP (1-17) functions as a specific antigenic peptide that binds to MHC class II molecules (e.g., I-Aᵇ, I-Aᵘ in mice) with high affinity, facilitating presentation to autoreactive CD4⁺ T cells.
Activation of these T cells triggers the release of pro-inflammatory cytokines (e.g., IFN-γ, IL-17) and the recruitment of immune cells to the central nervous system (CNS), mimicking the pathological cascade of MS.
Unlike modified MBP analogs, its native sequence retains physiological relevance, enabling accurate characterization of MHC-peptide-TCR interactions and T-cell-mediated neuroinflammation.
2.PRODUCT INDICATIONS
Research Use Only (RUO): Designed for in vitro and in vivo studies of MS pathogenesis, EAE induction, and autoimmune T-cell responses.
Ideal for investigating antigen presentation, T-cell activation, and the efficacy of immunomodulatory therapies (e.g., peptide vaccines, monoclonal antibodies, small-molecule inhibitors).
Suitable for tolerance-induction experiments, CNS autoimmunity modeling, and validation of MS-related therapeutic targets.
3.CLINICAL EFFICACY OF PRODUCT
MBP (1-17) is a preclinical research reagent and has not undergone human clinical trials.
In murine EAE models, it consistently induces a reproducible, dose-dependent autoimmune response, serving as a gold-standard positive control for evaluating the efficacy of potential MS therapies.
Its well-characterized activity profile supports the validation of novel treatments targeting T-cell activation, MHC-peptide binding, or neuroinflammation in preclinical development.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
