Ac-MBP (4-14) Peptide

Ac-MBP (4-14) Peptide is an N-terminally acetylated synthetic peptide fragment corresponding to amino acid residues 4-14 of the myelin basic protein (MBP). This specific chemical modification enhances the peptide's stability and mimics a common natural post-translational modification, making it a refined and reliable research-grade reagent for advanced immunological and neurological studies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Acetyl-Myelin Basic Protein (4-14) Peptide
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C62H105N21O18
Molecular Weight	1432.7g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in deionized water, dilute hydrochloric acid (0.01M) and neutral buffers
Endotoxin	< 1.0 EU/mg
Biological Activity	Acetylated encephalitogenic epitope of myelin basic protein (MBP)
Storage Conditions	Store at -20°C in a hermetically sealed container under dry conditions
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The acetylation at the N-terminus increases the peptide's resistance to exopeptidase degradation, prolonging its half-life in biological assays. As a truncated and modified core epitope derived from the immunodominant region of MBP, it retains the capacity to be presented by Major Histocompatibility Complex (MHC) Class II molecules. This presentation engages with T-cell receptors (TCRs) with altered avidity and kinetics compared to the native sequence, allowing researchers to probe the subtleties of antigen processing, TCR recognition, and immune synapse formation in autoimmune models.

2.PRODUCT INDICATIONS

This product is indicated for sophisticated research in immunology and neurobiology. Its primary uses include: studying the impact of N-terminal acetylation on antigenicity and immunogenicity, serving as a stabilized antigen in T-cell stimulation and proliferation assays, investigating altered peptide ligand (APL) strategies for immune modulation, and acting as a precise tool for epitope mapping and TCR specificity studies related to experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS).

3.CLINICAL EFFICACY OF PRODUCT

Ac-MBP (4-14) Peptide is a research tool and not a direct clinical therapeutic. Its efficacy is demonstrated in the research setting, where its enhanced stability provides more consistent and reproducible results in vitro and in vivo. Studies utilizing such stabilized analogs contribute to the foundational understanding of antigen-TCR interactions, aiding in the rational design of next-generation antigen-specific therapies and diagnostic tools for autoimmune demyelinating diseases.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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