δ1-MSH, amide CAS NO.72629-65-3

δ1-MSH, amide is a synthetic, C-terminally amidated analog of the delta-melanocyte-stimulating hormone (δ-MSH) peptide. This modification enhances its metabolic stability and receptor binding affinity compared to its non-amidated counterpart. As a high-purity, research-grade neuropeptide, it serves as a crucial tool for investigating the melanocortin system, particularly the roles of the melanocortin 3 receptor (MC3R) in energy homeostasis and neuroendocrine functions.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	δ1-MSH, amide
CAS NO.	72629-65-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C72H97N21O14S
Molecular Weight	1512.8g/mol
Purity (RP-HPLC)	≥ 98%
Solubility	Soluble in deionized water, dilute acetic acid (0.1% v/v) and neutral phosphate buffers
Endotoxin	< 1.0 EU/mg
Biological Activity	Bioactive melanocortin peptide analog; binds to melanocortin receptors (MCRs) with high affinity, exerting anti-inflammatory, antipyretic and immunomodulatory effects
Storage Conditions	Store at -20°C in a tightly sealed container under desiccation.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide acts as a potent agonist primarily at the melanocortin 3 receptor (MC3R), and also exhibits significant affinity for the melanocortin 4 receptor (MC4R). The C-terminal amidation significantly improves its resistance to degradation by carboxypeptidases, leading to increased bioavailability and prolonged action. Upon receptor binding, it activates intracellular signaling cascades (increased cAMP production) that modulate neuronal activity in key brain regions involved in appetite regulation, energy expenditure, and metabolic control.

2.PRODUCT INDICATIONS

This product is indicated for in vitro and in vivo research in neuroendocrinology, metabolism, and pharmacology. Key applications include: studying the specific physiological roles of MC3R in energy balance and feeding behavior, investigating potential therapeutic targets for obesity and eating disorders, and serving as a reference agonist for receptor binding assays and functional screening of melanocortin receptor ligands.

3.CLINICAL EFFICACY OF PRODUCT

δ1-MSH, amide is a preclinical research compound. While not a direct therapeutic, its robust pharmacological profile makes it an invaluable tool for proof-of-concept studies. Research using this stable analog has significantly advanced the understanding of MC3R's distinct role from MC4R in metabolism, helping to validate the MC3R pathway as a potential target for next-generation weight management and metabolic syndrome therapies currently under investigation.

4.DELIVERY & SHIPPING

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