β-MSH, human

β-MSH, Human (CAS NO.: 17908-57-5) is an endogenous peptide hormone and neuropeptide belonging to the melanocortin family, derived from proopiomelanocortin (POMC). With a molecular formula of C118H174N34O35S and a molecular weight of 2660.9, this 22-amino-acid linear polypeptide (sequence: AEKKDEGPYRMEHFRWGSPPKD) acts as a potent agonist of melanocortin receptors (MC1R, MC3R, MC4R, MC5R). It exhibits multiple physiological activities, including regulating skin pigmentation, inhibiting food intake, modulating energy metabolism, and exerting anti-inflammatory effects. Our β-MSH, Human is supplied with high purity (≥98% HPLC) and stable quality, suitable for scientific research, pharmaceutical R&D, and biochemical experiment applications.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	β-MSH, human
CAS NO.	17908-57-5
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₁₈H₁₇₄N₃₄O35S
Molecular Weight	2660.9g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, 1% acetic acid, or dilute aqueous buffers
Endotoxin	< 1.0 EU/mg
Biological Activity	A potent melanocortin receptor agonist that binds to MC1, MC3, MC4, and MC5 receptors. It regulates pigmentation, anti-inflammatory responses, energy homeostasis, and immune function. Its activity is validated via cAMP accumulation assays in melanocortin receptor-expressing cell lines.
Storage Conditions	Store at -20°C in a desiccated environment. Avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

β-MSH, Human exerts its biological effects primarily by binding to specific melanocortin receptors (MCRs) in various tissues and activating downstream signaling pathways. For skin pigmentation regulation, it binds to MC1R on melanocytes, activating the G-protein-coupled signaling pathway to increase intracellular cyclic adenosine monophosphate (cAMP) levels. Elevated cAMP further activates protein kinase A (PKA), which phosphorylates the microphthalmia-associated transcription factor (MITF), upregulating the expression of tyrosinase and other melanin-synthesis-related genes, thereby promoting melanin production and secretion.

2.PRODUCT INDICATIONS

Skin pigmentation research: Exploration of melanin synthesis mechanisms and the development of whitening or tanning-related research tools.

Metabolic disorder research: Investigation of appetite regulation, energy balance, and potential targets for obesity and metabolic syndrome treatment.

Inflammatory response research: Development of anti-inflammatory drugs and immunomodulators based on its anti-inflammatory properties.

3.CLINICAL EFFICACY OF PRODUCT

β-MSH, Human is in the preclinical research stage, and its potential clinical efficacy has been verified in multiple in vitro and in vivo studies. In animal experiments, it has been shown to significantly inhibit food and water intake in chicks and rats, demonstrating its potential in regulating energy metabolism and weight control. In anti-inflammatory research, it effectively suppresses LPS-induced NF-κB nuclear translocation and NO overproduction in brain tissues, indicating promising applications in treating neuroinflammatory diseases.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.