γ3-MSH CAS NO.72629-64-2

γ3-MSH (Gamma-3-Melanocyte-Stimulating Hormone) is a synthetic neuropeptide corresponding to the C-terminal fragment of the pro-opiomelanocortin (POMC) precursor protein. It is a distinct member of the melanocortin peptide family, recognized for its potent agonistic activity primarily at the melanocortin 3 receptor (MC3R). This high-purity, research-grade peptide is a vital tool for dissecting the complex roles of melanocortin signaling in metabolism, cardiovascular function, and neuroendocrine regulation.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	γ3-MSH
CAS NO.	72629-64-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C126H188N44O37S
Molecular Weight	2943.2g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in deionized water, dilute acetic acid (0.1% v/v) and neutral phosphate buffers (PBS pH 7.0-7.4)
Endotoxin	≤5 EU/mg
Biological Activity	Endogenous melanocortin family peptide
Storage Conditions	Store at -20°C in a tightly sealed container under desiccation; aliquot into small volumes upon first use to avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

γ3-MSH functions as a selective endogenous agonist for the melanocortin 3 receptor (MC3R), with lower affinity for other melanocortin receptors. Upon binding to MC3R, predominantly expressed in the brain and peripheral tissues, it activates the Gs protein-coupled signaling pathway, leading to increased intracellular cyclic adenosine monophosphate (cAMP) levels. This activation modulates neuronal circuits involved in energy balance, influences aldosterone secretion, and participates in the central control of blood pressure and inflammatory responses.

2.PRODUCT INDICATIONS

This product is indicated for preclinical research in physiology, pharmacology, and endocrinology. Its primary applications include: investigating the specific physiological functions of the MC3 receptor, studying central and peripheral mechanisms of energy homeostasis and feeding behavior, exploring cardiovascular regulation and aldosterone secretion, and serving as a selective reference agonist in receptor binding and functional assays for melanocortin receptor subtype characterization.

3.CLINICAL EFFICACY OF PRODUCT

γ3-MSH is a fundamental research tool, not a direct therapeutic agent. Its efficacy lies in its role as a key pharmacological probe. Studies utilizing γ3-MSH have been instrumental in elucidating the unique, non-redundant roles of MC3R in metabolism (distinct from MC4R) and cardiovascular function. This research provides critical insights that inform the development of novel, receptor-subtype-targeted therapeutics for conditions like obesity, metabolic syndrome, and hypertension.

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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