Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse) CAS NO.162558-10-3

Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse) is a synthetic peptide fragment corresponding to amino acid residues 185-193 of the PMEL17/gp100 protein, a melanocyte differentiation antigen expressed in melanoma cells. This research-grade reagent is provided as a lyophilized powder with high purity and is designed for immunological studies in cancer research, particularly focusing on melanoma immunology. The peptide sequence (KTWGEYFP) is conserved across human, bovine, and mouse species, making it suitable for cross-species comparative studies and translational research applications in both academic and pharmaceutical research settings.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse)
CAS NO.	162558-10-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C46H72N10O15
Molecular Weight	1005.14g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	It is readily soluble in water, physiological saline, or PBS buffer. It is recommended to prepare a stock solution of 1-10 mg/mL using sterile water or PBS, aliquot, and store at ≤-20°C. It is also soluble in a small amount of DMSO (<1%), followed="" by="" dilution="" with="" experimental="" buffer.="">
Endotoxin	< 1.0 EU/mg
Biological Activity	This peptide is a potential immunoepitaph of the melanoma-associated antigen PMEL17/gp100, which can be recognized by specific HLA-restricted cytotoxic T lymphocytes. In in vitro experiments, it may be used to assess the proliferation and cytokine secretion responses of antigen-specific CTLs. Specific activity and HLA restriction need to be verified through T cell activation assays and with reference to the latest literature.
Storage Conditions	Store at -20°C or lower in a dry environment away from light; it is stable for a long time. After reconstitution: Aliquot and freeze at ≤-20°C or -80°C, avoiding repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The mechanism of action involves the presentation of this peptide by specific major histocompatibility complex (MHC) class I molecules on antigen-presenting cells, where it can be recognized by CD8+ cytotoxic T lymphocytes (CTLs) through their T-cell receptors. This peptide-MHC complex engagement triggers CTL activation and proliferation, potentially leading to the generation of antigen-specific immune responses against cells expressing the PMEL17/gp100 antigen. The conserved nature of this epitope across species allows for its use in various experimental models to study T-cell recognition and immune activation mechanisms in the context of melanoma and other cancers.

2.PRODUCT INDICATIONS

This PMEL17 peptide is indicated for research use only in the fields of tumor immunology, cancer immunotherapy, and melanoma research. It serves as a potential antigenic stimulus in studies investigating T-cell responses, epitope mapping, and the development of cancer vaccine candidates. The product is used as a research reagent for characterizing antigen-specific immune responses, validating diagnostic assays, and evaluating immunotherapeutic approaches in preclinical models. It is also employed in cell-based assays to study antigen presentation and T-cell activation in both in vitro and in vivo experimental systems.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, Melanocyte Protein PMEL 17 (185-193) does not have established clinical efficacy for therapeutic use in human patients. Its utility is confined to preclinical research applications, where it has been used to study melanoma immunology and explore potential immunotherapeutic strategies. While research using this peptide may contribute to the understanding of tumor antigen-specific immune responses, the product itself has not been evaluated in clinical trials for safety or efficacy. Any potential clinical applications derived from research findings would require separate development of therapeutic products that undergo rigorous clinical testing and regulatory approval processes.

4.DELIVERY & SHIPPING

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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Main Method: International Air Freight

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