α-MSH, Free Acid

α-MSH, Free Acid is a naturally occurring neuropeptide and member of the melanocortin family, derived from the precursor protein proopiomelanocortin (POMC). With a molecular formula of C77H108N20O20Sand a molecular weight of 1665.91 g/mol .It is a potent, non-selective agonist of melanocortin receptors (MC1R, MC3R, MC4R, MC5R) and exhibits diverse physiological functions, including regulating skin pigmentation, modulating appetite, controlling energy metabolism, and exerting anti-inflammatory and immunomodulatory effects. Our α-MSH, Free Acid is manufactured with strict quality control, making it ideal for scientific research, pharmaceutical R&D, and biochemical experimentation.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	α-MSH, Free Acid
CAS NO.	\
Appearance	White to off-white lyophilized powder
Molecular Formula	C77H108N20O20S
Molecular Weight	1665.91g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥1 mg/mL), PBS buffer (pH 7.4), and DMSO; slightly soluble in ethanol
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent agonist of melanocortin receptors (MC1R, MC3R, MC4R, MC5R); EC50 < 1 nM for MC1R binding
Storage Conditions	-20°C for long-term storage (stable for 2 years); avoid repeated freeze-thaw cycles; store desiccated
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The biological effects of α-MSH, Free Acid are primarily mediated through its high-affinity binding to melanocortin receptors (MCRs), a family of G-protein-coupled receptors (GPCRs) distributed across various tissues. In melanocytes, binding to MC1R activates the cAMP/PKA signaling pathway, which phosphorylates the microphthalmia-associated transcription factor (MITF). Phosphorylated MITF upregulates the expression of tyrosinase, tyrosinase-related protein 1 (TRP-1), and TRP-2—key enzymes in melanin synthesis—thereby promoting melanin production and skin pigmentation.

2.PRODUCT INDICATIONS

Skin pigmentation research: Investigation of melanin synthesis mechanisms, development of tools for studying hypopigmentation disorders (e.g., vitiligo) and hyperpigmentation conditions.

Metabolic and weight management research: Exploration of appetite regulation pathways and potential therapeutic targets for obesity, diabetes, and metabolic syndrome.

Anti-inflammatory and immunology research: Development of novel anti-inflammatory agents for treating neuroinflammation, autoimmune diseases, and inflammatory skin conditions.

3.CLINICAL EFFICACY OF PRODUCT

α-MSH, Free Acid is currently in preclinical and early clinical research stages, with promising efficacy demonstrated in multiple in vitro and in vivo models. In animal studies, it has shown significant ability to promote melanin synthesis, providing a potential research basis for treating vitiligo—clinical trials are underway to evaluate its efficacy in repigmenting depigmented skin lesions.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.