[Des-Acetyl]-a-MSH CAS NO.53697-27-1

[Des-Acetyl]-α-MSH (CAS NO. 53697-27-1) is a synthetic peptide analog of α-Melanocyte-Stimulating Hormone (α-MSH) that lacks the N-terminal acetyl group. This deacetylated form is a native variant and a high-purity research tool used to study the critical role of N-acetylation in melanocortin peptide stability, receptor binding affinity, and biological activity, particularly within the melanocortin-1 receptor (MC1R) pathway.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Des-Acetyl]-a-MSH
CAS NO.	53697-27-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C75H107N21O18S
Molecular Weight	1622.88g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥50 mg/mL), dilute acetic acid, or 1% ammonium hydroxide
Endotoxin	< 1.0 EU/mg
Biological Activity	Soluble in water (≥50 mg/mL), dilute acetic acid, or 1% ammonium hydroxide
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide acts as a melanocortin receptor agonist but with altered pharmacokinetics compared to its acetylated counterpart. The absence of the N-terminal acetyl group significantly reduces its resistance to aminopeptidase degradation, leading to a shorter half-life in biological systems. It retains the ability to bind to and activate melanocortin receptors, especially MC1R, stimulating intracellular cAMP production, but with potentially different potency and duration of effect, making it a key tool for understanding structure-activity relationships.

2.PRODUCT INDICATIONS

This product is indicated for fundamental research in biochemistry, dermatology, and pharmacology. Key applications include: comparative studies on the impact of N-terminal acetylation on peptide stability and bioactivity, investigating melanocortin receptor pharmacology and signaling kinetics, serving as a control or precursor in studies of α-MSH metabolism, and exploring its role in pigmentation, inflammation, and immunomodulation pathways in research models.

3.CLINICAL EFFICACY OF PRODUCT

[Des-Acetyl]-α-MSH is a research compound, not a direct therapeutic. Its "efficacy" is defined by its utility as a comparative scientific probe. Research utilizing this analog has been pivotal in demonstrating how a single post-translational modification (acetylation) dramatically influences peptide hormone stability and potency. These insights are crucial for the rational design of stable and effective melanocortin-based therapeutics for skin disorders, inflammation, and other conditions.

4.DELIVERY & SHIPPING

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