DTrp-Gamma MSH
DTrp-Gamma MSH
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | DTrp-Gamma MSH |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C74H99N21O16S |
| Molecular Weight | 1570.81g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, physiological saline, or dilute acetic acid solution. It is recommended to first prepare a high-concentration stock solution (1-5 mg/mL) with a small amount of dilute acetic acid (<0.1% v=""> |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | DTrp-γ-MSH is a modified analogue of γ-melanocyte-stimulating hormone (γ-MSH), typically designed to selectively activate the melanocortin receptors MC3R and MC5R, and may enhance receptor binding affinity and metabolic stability through D-Trp substitution. Its biological activity needs to be validated through in vitro cAMP accumulation experiments (e.g., using cell lines expressing human MC3R/MC5R) or animal metabolic models. |
| Storage Conditions | Store at -20°C or lower in a dry, dark place for extended periods. Reconstituted solution: It is recommended to aliquot and freeze at ≤-20°C, avoiding repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The mechanism of action involves selective binding to and activation of melanocortin receptors, primarily MC3R and MC5R, which are G-protein coupled receptors expressed in various tissues including the hypothalamus and peripheral organs. Receptor engagement triggers intracellular cAMP accumulation through Gαs protein coupling, leading to downstream signaling cascades that modulate energy expenditure, appetite regulation, and metabolic processes. The D-Trp substitution enhances peptide stability against enzymatic degradation and improves receptor binding affinity, while the disulfide bridge (if present) stabilizes the peptide's secondary structure, collectively resulting in prolonged biological activity and improved selectivity compared to the native γ-MSH.
2.PRODUCT INDICATIONS
This DTrp-γ-MSH analog is indicated for research use only in preclinical studies investigating melanocortin receptor biology, energy metabolism, obesity and metabolic syndrome, and appetite regulation mechanisms. It serves as a selective melanocortin receptor agonist in receptor binding assays, functional assays measuring cAMP production or calcium mobilization, and animal models of metabolic disorders. The product is used to study the role of MC3R and MC5R in energy balance, glucose homeostasis, and cardiovascular regulation, as well as in structure-activity relationship studies for developing novel therapeutic compounds targeting melanocortin pathways. It is not intended for diagnostic, therapeutic, or clinical applications in humans or animals.
3.CLINICAL EFFICACY OF PRODUCT
As a research reagent, DTrp-γ-MSH does not have established clinical efficacy for therapeutic use in human patients. While this peptide analog and related compounds have been studied in preclinical models to understand melanocortin receptor physiology and its role in metabolic regulation, the product itself has not undergone clinical development or received regulatory approval for any medical indication. Research using this peptide has contributed to the understanding of melanocortin signaling in energy homeostasis and the identification of potential therapeutic targets for metabolic diseases, but the product remains an investigational research tool without proven clinical efficacy or safety profile for human use.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight
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