δ-MSH

δ-MSH (Delta-Melanocyte-Stimulating Hormone) is a synthetic peptide representing a naturally occurring endogenous melanocortin. It is a high-purity, research-grade agonist that exhibits a distinct and selective binding profile for melanocortin receptors, primarily the melanocortin 3 receptor (MC3R). This peptide is a crucial tool for dissecting the specific physiological roles of MC3R signaling in metabolism, energy homeostasis, and neuroendocrine regulation.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	δ-MSH
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C74H99N21O16S
Molecular Weight	1570.81g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥20 mg/mL), dilute hydrochloric acid, or DMSO
Endotoxin	< 1.0 EU/mg
Biological Activity	Agonist of melanocortin receptors (predominantly MC1R and MC5R); regulates pigmentation and exocrine gland function
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

δ-MSH functions as a potent endogenous agonist with high affinity and selectivity for the melanocortin 3 receptor (MC3R), and lesser affinity for MC4R and MC5R. Upon binding to MC3R, which is widely expressed in the brain, gut, and other peripheral tissues, it activates the Gs protein-coupled signaling pathway.

2.PRODUCT INDICATIONS

This product is indicated for advanced in vitro and in vivo research in neuroendocrinology, metabolism, and pharmacology. Key applications include: investigating the unique functions of MC3R in energy balance and glucose homeostasis, studying its role in appetite regulation and metabolic disorders, serving as a selective reference agonist in receptor binding and functional assays to characterize melanocortin receptor subtypes, and exploring its potential involvement in inflammation and cardiovascular control.

3.CLINICAL EFFICACY OF PRODUCT

δ-MSH is a fundamental research ligand and not a direct therapeutic. Its efficacy lies in its role as a highly selective pharmacological probe. Research utilizing δ-MSH has been instrumental in differentiating the physiological functions of MC3R from the closely related MC4R, providing critical evidence that MC3R plays a non-redundant role in nutrient partitioning and metabolic adaptation. This foundational work supports MC3R as a novel and promising target for the development of next-generation therapeutics for obesity, cachexia, and metabolic syndrome.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.