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Ac- [Nle4,DPhe7] a-MSH (4-10), amide

Ac-[Nle4,DPhe7] α-MSH (4-10), amide is a highly potent and stabilized synthetic analog of the core melanocyte-stimulating hormone (α-MSH) sequence. This research-grade peptide incorporates key modifications: N-terminal acetylation (Ac), norleucine substitution at position 4 (Nle4), D-phenylalanine at position 7 (DPhe7), and C-terminal amidation. These features collectively confer exceptional metabolic stability, prolonged biological half-life, and superagonist activity at melanocortin receptors (particularly MC1R), making it a premier tool for melanocortin research.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Ac-[Nle⁴,D-Phe⁷]-α-MSH (4-10), amide (Acetyl-Nle⁴,D-Phe⁷-alpha-MSH (4-10) amide)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C47H64N14O10
Molecular Weight	985.12g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥10 mg/mL), dilute acetic acid, or 10% DMSO in water
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent, selective agonist of melanocortin receptors (MC1R, MC3R, MC4R, MC5R)
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This analog acts as a potent superagonist at melanocortin receptors, primarily MC1R. The Nle4 substitution enhances hydrophobicity and receptor interaction, while the DPhe7 modification dramatically increases resistance to enzymatic degradation and stabilizes a bioactive conformation. Together, these changes result in significantly higher receptor binding affinity and functional potency (increased cAMP production) compared to the native α-MSH sequence.

2.PRODUCT INDICATIONS

This product is indicated for high-level in vitro and in vivo research in dermatology, pharmacology, and cell biology. It is the reference standard for: studying MC1R-mediated signaling pathways in melanogenesis and pigmentation, evaluating the pharmacology of melanocortin receptor agonists, serving as a positive control in cAMP accumulation assays, and investigating the role of α-MSH in inflammation, immunomodulation, and appetite regulation in experimental models.

3.CLINICAL EFFICACY OF PRODUCT

Ac-[Nle4,DPhe7] α-MSH (4-10), amide is a powerful research probe, not an approved drug. Its "efficacy" is defined by its robust and reliable performance in scientific studies. As one of the most potent α-MSH analogs known, it has been instrumental in validating MC1R as a therapeutic target. Its structural blueprint has directly informed the development of clinical-stage and approved therapeutics, such as the tanning agent afamelanotide (Scenesse®), for conditions like erythropoietic protoporphyria and vitiligo.

4.DELIVERY & SHIPPING

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