Ac- [Nle4,DPhe7] a-MSH (4-10), amide

Ac-[Nle4,DPhe7] α-MSH (4-10), amide is a highly potent and stabilized synthetic analog of the core melanocyte-stimulating hormone (α-MSH) sequence. This research-grade peptide incorporates key modifications: N-terminal acetylation (Ac), norleucine substitution at position 4 (Nle4), D-phenylalanine at position 7 (DPhe7), and C-terminal amidation. These features collectively confer exceptional metabolic stability, prolonged biological half-life, and superagonist activity at melanocortin receptors (particularly MC1R), making it a premier tool for melanocortin research.

Send Email

Download

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Ac-[Nle⁴,D-Phe⁷]-α-MSH (4-10), amide (Acetyl-Nle⁴,D-Phe⁷-alpha-MSH (4-10) amide)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C47H64N14O10
Molecular Weight	985.12g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥10 mg/mL), dilute acetic acid, or 10% DMSO in water
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent, selective agonist of melanocortin receptors (MC1R, MC3R, MC4R, MC5R)
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This analog acts as a potent superagonist at melanocortin receptors, primarily MC1R. The Nle4 substitution enhances hydrophobicity and receptor interaction, while the DPhe7 modification dramatically increases resistance to enzymatic degradation and stabilizes a bioactive conformation. Together, these changes result in significantly higher receptor binding affinity and functional potency (increased cAMP production) compared to the native α-MSH sequence.

2.PRODUCT INDICATIONS

This product is indicated for high-level in vitro and in vivo research in dermatology, pharmacology, and cell biology. It is the reference standard for: studying MC1R-mediated signaling pathways in melanogenesis and pigmentation, evaluating the pharmacology of melanocortin receptor agonists, serving as a positive control in cAMP accumulation assays, and investigating the role of α-MSH in inflammation, immunomodulation, and appetite regulation in experimental models.

3.CLINICAL EFFICACY OF PRODUCT

Ac-[Nle4,DPhe7] α-MSH (4-10), amide is a powerful research probe, not an approved drug. Its "efficacy" is defined by its robust and reliable performance in scientific studies. As one of the most potent α-MSH analogs known, it has been instrumental in validating MC1R as a therapeutic target. Its structural blueprint has directly informed the development of clinical-stage and approved therapeutics, such as the tanning agent afamelanotide (Scenesse®), for conditions like erythropoietic protoporphyria and vitiligo.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.