MSH Release Inhibiting Factor, amide CAS NO.2002-44-0
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | MSH Release Inhibiting Factor, amide |
| CAS NO. | 2002-44-0 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C13H24N4O3 |
| Molecular Weight | 284.36g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water (≥1 mg/mL), PBS buffer (pH 7.2–7.4), and DMSO; slightly soluble in methanol/ethanol |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Inhibits the release of α-MSH/β-MSH from the pituitary; modulates dopamine and serotonin pathways; EC₅₀ < 10 nM in in vitro release inhibition assays |
| Storage Conditions | -20°C (long-term, stable for 2 years); avoid repeated freeze-thaw; store desiccated |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
The core biological mechanism of MSH Release Inhibiting Factor, amide revolves around its regulatory effects on the hypothalamic-pituitary-adrenal (HPA) axis and neurotransmitter systems. It exerts its MSH-inhibiting activity by binding to specific receptors on pituitary melanotroph cells, suppressing the secretion of α-MSH and β-MSH through the inhibition of cyclic adenosine monophosphate (cAMP)-dependent signaling pathways. This action directly modulates skin pigmentation processes by reducing melanin synthesis downstream of MSH.
2.PRODUCT INDICATIONS
Neuroendocrine research: Investigation of the HPA axis regulation, MSH secretion mechanisms, and hypothalamic-pituitary signaling pathways.
Neuroscience research: Study of dopamine/serotonin pathway modulation, mood disorders, pain management, and neuroprotective strategies.
Skin pigmentation research: Exploration of melanin synthesis regulation and potential tools for hyperpigmentation disorder studies.
3.CLINICAL EFFICACY OF PRODUCT
MSH Release Inhibiting Factor, amide is currently in preclinical research and early-phase clinical exploration, with promising efficacy demonstrated in multiple in vitro and in vivo models. In animal studies, it has shown significant ability to inhibit pituitary MSH release, reducing skin pigmentation in rodent models—providing a potential research basis for treating hyperpigmentation disorders such as melasma.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
