[Des-Asp187]-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse) CAS NO.319927-23-6

[Des-Asp187]-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse) (CAS NO. 319927-23-6) is a synthetic, nonameric peptide corresponding to a conserved epitope of the PMEL17/gp100 protein with a specific deletion of aspartic acid at position 187. This modified, high-purity peptide is a critical research tool in immunology and oncology, specifically designed to study T-cell responses against melanoma and other melanocyte-derived malignancies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Des-Asp¹⁸⁷]-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse)
CAS NO.	319927-23-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C42H67N9O12
Molecular Weight	890.06g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥5 mg/mL), dilute acetic acid, or 5% DMSO in water
Endotoxin	< 1.0 EU/mg
Biological Activity	Melanoma-associated antigen peptide; used to induce antigen-specific T-cell responses, for cancer immunology research and vaccine development
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide functions as an altered peptide ligand (APL) derived from the melanocyte differentiation antigen PMEL17/gp100. The deletion of Asp187 ([Des-Asp187]) modifies its structural and charge properties, potentially altering its processing by antigen-presenting cells and its subsequent presentation by HLA class I molecules (commonly HLA-A*0201). This modification can lead to differential activation of cytotoxic T lymphocytes (CTLs), allowing for the study of T-cell receptor (TCR) affinity, cross-reactivity, and the induction of specific immune responses against tumor cells expressing the wild-type gp100 antigen.

2.PRODUCT INDICATIONS

This product is indicated for immunological and cancer research. Key applications include: investigating T-cell recognition and cross-reactivity in melanoma immunotherapy, studying altered peptide ligand (APL) strategies to enhance or modulate anti-tumor immunity, evaluating the efficacy of adoptive T-cell therapies and peptide vaccines in preclinical models, and serving as a key antigen in immunological assays such as ELISpot, MHC multimer staining, and T-cell stimulation assays.

3.CLINICAL EFFICACY OF PRODUCT

4.DELIVERY & SHIPPING

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