Melanocyte Associated Antigen gp 100 (17 – 25)

Melanocyte Associated Antigen gp100 (17-25) is a synthetic peptide epitope corresponding to amino acid residues 17-25 of the human glycoprotein 100 (gp100 or PMEL17). This nonameric peptide is a well-characterized, HLA-A*0201-restricted antigenic determinant and serves as a fundamental research-grade reagent for studying cytotoxic T-lymphocyte (CTL) responses against melanoma and other pigment cell-derived cancers.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Melanocyte Associated Antigen gp100 (17-25)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C38H70N10O11
Molecular Weight	843.04g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥5 mg/mL), dilute acetic acid, or 5% DMSO in water
Endotoxin	< 1.0 EU/mg
Biological Activity	HLA-A3-restricted melanoma-associated epitope; induces tumor-specific T-lymphocyte responses; used in cancer immunology research and vaccine development.
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide is processed intracellularly and presented on the surface of antigen-presenting cells (APCs) or melanoma tumor cells in complex with HLA-A*0201 molecules. When recognized by specific CD8+ T-cell receptors (TCRs) on circulating CTLs, it triggers T-cell activation, proliferation, and the release of cytolytic granules (perforin, granzymes). This leads to the targeted lysis and elimination of gp100-expressing tumor cells, constituting a core mechanism of tumor-specific adaptive immunity.

2.PRODUCT INDICATIONS

This product is indicated for in vitro and ex vivo research in tumor immunology and immunotherapy development. Key applications include: monitoring and expanding tumor-infiltrating lymphocytes (TILs) or peripheral blood CTLs specific for melanoma, evaluating the immunogenicity of gp100-targeted cancer vaccines, serving as a critical antigen in MHC multimer staining (e.g., tetramers) for T-cell detection, and conducting T-cell activation and functional assays (ELISpot, intracellular cytokine staining) for both basic research and clinical trial immune monitoring.

3.CLINICAL EFFICACY OF PRODUCT

As a research tool, this peptide itself is not a therapeutic. However, its use has been integral to the clinical development of gp100-targeted immunotherapies. The gp100(17-25) epitope has been a central component in numerous clinical trials involving peptide vaccines and adoptive T-cell transfer for metastatic melanoma.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.