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γ-MSH (3-8) CAS NO.98640-70-1

γ-MSH (3-8) (CAS NO. 98640-70-1) is a synthetic hexapeptide fragment corresponding to residues 3-8 of the gamma-Melanocyte-Stimulating Hormone (γ-MSH). This short, stable, and high-purity sequence retains core structural motifs that confer specific binding activity. It is an essential research-grade tool for investigating the structure-activity relationships and selective signaling functions of γ-MSH-derived peptides, particularly within the melanocortin receptor system.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	γ-MSH (3-8)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C39H52N12O7S
Molecular Weight	832.98 g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥20 mg/mL), dilute acetic acid, or 5% DMSO in aqueous buffer
Endotoxin	< 1.0 EU/mg
Biological Activity	Agonist of melanocortin receptors (MC1R, MC3R, MC5R); modulates pigmentation, anti-inflammatory responses and energy metabolism
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This short peptide fragment functions as a ligand for melanocortin receptors (MCRs). While its shorter length typically reduces overall receptor affinity compared to full-length γ-MSH, the γ-MSH (3-8) core sequence is critical for receptor interaction and can retain partial agonist or antagonist activity depending on the receptor subtype (primarily MC3R).

2.PRODUCT INDICATIONS

This product is indicated for fundamental research in neuroendocrinology, pharmacology, and peptide chemistry. Key applications include: studying the minimal active sequence and structure-activity relationship (SAR) of γ-MSH, investigating selective binding and functional profiles at melanocortin receptor subtypes (MC3R/MC4R), developing radiolabeled ligands or fluorescent probes for receptor binding assays, and serving as a reference standard in the synthesis and screening of novel melanocortin peptide analogs.

3.CLINICAL EFFICACY OF PRODUCT

γ-MSH (3-8) is a basic research tool and not a therapeutic agent. Its efficacy is defined by its role in elucidating the core pharmacophore of γ-MSH. Research using this and similar fragments has been crucial for mapping the critical binding regions of melanocortin peptides. This foundational knowledge aids in the rational, fragment-based design of highly selective, stable, and potent melanocortin receptor agonists or antagonists with potential future clinical applications in metabolic disorders, inflammation, or cardiovascular diseases.

4.DELIVERY & SHIPPING

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