Myelin Oligodendrocyte Glycoprotein(35-55), rat MOG(35-55) CAS NO.149635-73-4

Myelin Oligodendrocyte Glycoprotein (35-55), rat [MOG (35-55)] (CAS NO. 149635-73-4) is a synthetic peptide corresponding to amino acid residues 35-55 of the rat MOG protein. This highly immunogenic peptide is the gold-standard antigen for inducing chronic experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice and other susceptible rodent strains, serving as a premier research tool for modeling multiple sclerosis (MS) and studying neuroinflammation.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Myelin Oligodendrocyte Glycoprotein (35-55), rat MOG(35-55)
CAS NO.	149635-73-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C118H177N35O29S
Molecular Weight	2582g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥10 mg/mL), dilute acetic acid, 10% DMSO in aqueous buffer
Endotoxin	≤1.0 EU/mg
Biological Activity	Immunodominant encephalitogenic epitope of rat MOG; induces experimental autoimmune encephalomyelitis (EAE)
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide acts as a potent encephalitogenic epitope. When emulsified with an adjuvant (like Complete Freund's Adjuvant) and administered to susceptible rodents, it is taken up by antigen-presenting cells, processed, and presented on MHC Class II molecules (specifically I-A⁰). This presentation activates autoreactive CD4⁺ T helper cells (Th1 and Th17 subsets), which migrate to the central nervous system.

2.PRODUCT INDICATIONS

This product is indicated exclusively for preclinical research in neuroimmunology and autoimmune diseases. Its primary and essential application is the reliable induction of the MOG₃₅₋₅₅ EAE model. It is also used for: investigating the pathogenesis of demyelination, evaluating the efficacy and mechanisms of potential therapies for MS, studying T-cell epitope specificity, immune tolerance, and the role of B cells/antibodies in neuroinflammation.

3.CLINICAL EFFICACY OF PRODUCT

MOG (35-55) peptide is a research reagent and not a human therapeutic. Its efficacy is defined by its unparalleled ability to induce a highly reproducible, chronic-progressive or relapsing-remitting EAE disease course that closely mirrors key aspects of human MS. This model has been instrumental in validating the autoimmune basis of MS and serves as the primary preclinical platform for testing nearly all modern immunomodulatory and neuroprotective drugs for MS, directly linking its use to clinical advancement.

4.DELIVERY & SHIPPING

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