α-ANF(1-28), human CAS NO.91917-63-4

α-Atrial Natriuretic Factor (1-28), human (CAS NO. 91917-63-4) is a synthetic, 28-amino acid peptide that corresponds to the full-length, biologically active form of the human atrial natriuretic peptide (ANP). This high-purity, research-grade hormone is a critical tool for studying cardiovascular and renal physiology, renowned for its potent natriuretic, diuretic, and vasodilatory effects.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	α-ANF(1-28), human
CAS NO.	91917-63-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C127H203N45O39S3
Molecular Weight	3080.46g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥10 mg/mL), dilute acetic acid, 5% DMSO in phosphate-buffered saline (PBS)
Endotoxin	< 1.0 EU/mg
Biological Activity	Endogenous cardiac hormone; binds to natriuretic peptide receptors (NPR-A/NPR-B)
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide functions as an endogenous ligand for the natriuretic peptide receptor A (NPR-A/GCCA). Upon binding, it activates the receptor's intrinsic guanylyl cyclase activity, leading to a sharp increase in intracellular cyclic guanosine monophosphate (cGMP) levels in target tissues (vascular smooth muscle, kidney, adrenal glands).

2.PRODUCT INDICATIONS

This product is indicated for in vitro and in vivo research in cardiovascular biology, nephrology, and endocrinology. Key applications include: studying the molecular pathways of blood pressure regulation and fluid balance, investigating heart-kidney interactions in hypertension and heart failure models, serving as a reference standard in receptor binding and cGMP stimulation assays, and exploring its anti-fibrotic and anti-hypertrophic effects in preclinical studies.

3.CLINICAL EFFICACY OF PRODUCT

As a research compound, α-ANF(1-28) itself is not an approved drug. However, its profound biological effects have made it a prototype for therapeutic development. Clinical research on native ANP and its analogs (e.g., carperitide) has demonstrated efficacy in acute heart failure by improving hemodynamics and promoting diuresis.

4.DELIVERY & SHIPPING

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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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