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[Leu144,Arg147]-Myelin Proteolipid Protein(139-151) CAS NO.188859-65-6
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | [Leu¹⁴⁴,Arg¹⁴⁷]‑Myelin Proteolipid Protein (139‑151) |
| CAS NO. | 188859‑65‑6 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C67H110N20O17 |
| Amino Acid Sequence | H‑Gln‑Arg‑Phe‑Ser‑Leu‑Val‑His‑Leu‑Phe‑Arg‑Val‑His‑Pro‑OH (with Leu at position 144, Arg at position 147 relative to full‑length PLP) |
| Molecular Weight | 1467.75g/mol |
| Purity (RP-HPLC) | ≥95.0% (can be customized to ≥98.0%) |
| Solubility | Soluble in water, PBS, or dilute acetic acid solution |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Modified myelin proteolipid protein epitope; used in multiple sclerosis (MS) research, autoimmune encephalomyelitis (EAE) models, and T‑cell epitope mapping. |
| Storage Conditions | Store at –20°C, protected from light and moisture. For long‑term storage, recommend –80°C. |
| Stock Location | Stock in USA |
| MOQ | 1mg |
1.MECHANISM OF ACTION
This modified peptide functions as an immunogenic epitope that is recognized by autoreactive T‑cells in the context of major histocompatibility complex (MHC) molecules. It can induce experimental autoimmune encephalomyelitis (EAE) in susceptible animal models, thereby simulating the autoimmune attack on myelin observed in diseases like multiple sclerosis.
2.PRODUCT INDICATIONS
[Leu¹⁴⁴,Arg¹⁴⁷]-Myelin Proteolipid Protein (139-151) is primarily used in preclinical research to model multiple sclerosis, investigate T‑cell mediated autoimmunity, and evaluate potential immunomodulatory or neuroprotective therapies. It is also applied in epitope mapping and immunological assay development.
3.CLINICAL EFFICACY OF PRODUCT
In experimental models, this peptide effectively induces EAE, providing a valuable tool for studying disease pathogenesis and screening therapeutic candidates. While not a clinical therapeutic itself, it contributes significantly to the understanding of myelin‑directed autoimmunity and supports the development of novel treatments for demyelinating disorders.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
