Atrial Natriuretic Peptide (126-149) (rat) CAS NO.91421-87-3

Atrial Natriuretic Peptide (126-149) (rat) (CAS NO. 91421-87-3) is a synthetic 24-amino acid peptide corresponding to the biologically active C-terminal fragment of rat pro-atrial natriuretic peptide (pro-ANP). This high-purity research reagent represents a key circulating form of ANP and is an essential tool for studying the specific physiological and pharmacological effects of this hormone in rodent models of cardiovascular and renal function.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Atrial Natriuretic Peptide (126-149) (rat)
CAS NO.	91421-87-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C104H168N38O33S2
Molecular Weight	2542.86g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water (≥ 10 mg/mL), dilute acids, or DMSO
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent natriuretic, diuretic, and vasorelaxant activity
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide fragment is a potent endogenous agonist for natriuretic peptide receptors, primarily the guanylyl cyclase-A (GC-A/NPR-A) receptor. Upon binding, it activates the receptor's intrinsic guanylyl cyclase domain, leading to a rapid increase in intracellular cyclic guanosine monophosphate (cGMP) levels.

2.PRODUCT INDICATIONS

This product is indicated for preclinical research in cardiovascular physiology, nephrology, and endocrinology using rat models. Key applications include: investigating the mechanisms of blood pressure regulation and fluid-electrolyte balance, studying the pathophysiology and treatment of hypertension, heart failure, and renal diseases in rodents, serving as a precise reference standard in receptor binding assays and cGMP stimulation studies, and exploring ANP's roles in cardiac hypertrophy and fibrosis.

3.CLINICAL EFFICACY OF PRODUCT

Atrial Natriuretic Peptide (126-149) (rat) is a research tool specific to rodent studies and not a human therapeutic. Its efficacy is defined by its ability to faithfully replicate the biological actions of endogenous ANP in rat models. Research utilizing this specific fragment has been crucial for elucidating the detailed cardiorenal functions of ANP in vivo, providing the foundational data that supports the therapeutic targeting of the natriuretic peptide system. This work directly informs the development of related drugs (e.g., nesiritide, sacubitril/valsartan) and biomarkers (BNP/NT-proBNP) used in human medicine.

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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