C-Type Natriuretic Peptide (1-53) (human) CAS NO.141294-77-1

C-Type Natriuretic Peptide (1-53) (human) (CAS NO. 141294-77-1) is a synthetic, full-length 53-amino acid peptide representing the complete, biologically active form of human CNP. This high-purity, research-grade peptide is a crucial endogenous ligand for the natriuretic peptide receptor B (NPR-B/GC-B) and serves as a fundamental tool for studying cardiovascular development, endochondral bone growth, and vascular biology.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	C-Type Natriuretic Peptide (1-53) (human)
CAS NO.	141294-77-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C251H417N81O71S3
Molecular Weight	5801.81g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥1 mg/mL), dilute acetic acid, or 0.1% TFA in water; sparingly soluble in methanol
Endotoxin	≤1.0 EU /mg
Biological Activity	Potent vasorelaxant activity; EC₅₀ typically in the range of 0.1–1.0 nM in isolated vascular tissue assays.
Storage Conditions	Store at ≤ -20°C in a dry, dark environment.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide specifically binds to and activates the natriuretic peptide receptor B (NPR-B), which possesses intrinsic guanylyl cyclase activity. The binding leads to a significant increase in intracellular cyclic guanosine monophosphate (cGMP) production in target cells.

2.PRODUCT INDICATIONS

This product is indicated for in vitro and in vivo research in endocrinology, skeletal biology, and cardiovascular science. Key applications include: studying the regulation of endochondral ossification and bone growth disorders, investigating CNP's role in cardiovascular homeostasis and vascular remodeling, serving as the definitive reference agonist in NPR-B receptor binding and functional (cGMP) assays, and exploring potential therapeutic applications for skeletal dysplasias (e.g., achondroplasia) and pulmonary hypertension.

3.CLINICAL EFFICACY OF PRODUCT

Human CNP(1-53) is a research peptide and not an approved drug. However, its profound biological role as the primary activator of the NPR-B/cGMP pathway in growth plates makes it a direct therapeutic prototype. Research using this peptide has validated CNP supplementation as a treatment strategy for growth disorders.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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