Dendroaspis Natriuretic Peptide

Dendroaspis Natriuretic Peptide (DNP) is a bioactive peptide originally derived from the venom of the green mamba (Dendroaspis angusticeps), known for its potent natriuretic and vasodilatory properties. This synthetic, high‑purity peptide is designed for research into cardiovascular and renal physiology, offering a unique tool to study fluid‑balance regulation, blood‑pressure modulation, and cardiac‑remodeling pathways. With its well‑characterized structure and reproducible activity, DNP serves as a valuable reference compound for academic, pharmaceutical, and biotechnology research aimed at understanding natriuretic‑peptide signaling and developing novel therapeutic strategies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Dendroaspis Natriuretic Peptide
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C180H282N56O56S2
Molecular Weight	4190.72g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute acetic acid (e.g., 0.1%), or phosphate-buffered saline (PBS). For best results, first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–0.5 mg/mL stock solution, then dilute further with assay buffer.
Endotoxin	< 1.0 EU/mg
Biological Activity	DNP is a potent vasodilatory and natriuretic peptide isolated from the venom of the green mamba (Dendroaspis angusticeps). It activates all three known natriuretic peptide receptors (NPR-A, NPR-B, NPR-C) with high affinity, leading to increased intracellular cGMP, vasodilation, natriuresis, and diuresis. Its activity is often confirmed by in vitroguanylyl cyclase activation assays or in vivoblood pressure reduction models.
Storage Conditions	Lyophilized powder: Store desiccated at –20°C or below, protected from light, for long-term stability. Reconstituted solution: Aliquot and store at ≤ –20°C or –80°C; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide exerts its effects primarily by binding to and activating all three known natriuretic peptide receptors (NPR‑A, NPR‑B, and NPR‑C). This binding stimulates intracellular guanylyl cyclase activity, leading to a marked increase in cyclic GMP (cGMP) levels and subsequent activation of cGMP‑dependent protein kinases. The resulting signaling cascade promotes vasodilation, enhances renal sodium and water excretion (natriuresis and diuresis), and inhibits the renin‑angiotensin‑aldosterone system. Its multi‑receptor engagement, coupled with a high affinity for the clearance receptor NPR‑C, contributes to a pronounced and sustained biological response, making it a potent pharmacological tool for manipulating cardiovascular and renal function.

2.PRODUCT INDICATIONS

Dendroaspis Natriuretic Peptide is indicated for research use only in preclinical investigations of cardiovascular and renal disorders, including heart failure, hypertension, volume overload, and related conditions where fluid and electrolyte homeostasis is disrupted. It is employed as a reference agonist in receptor‑binding assays, cGMP‑accumulation studies, and in vitro models of vascular relaxation and renal‑tubule transport. Additionally, the peptide is used in animal models to evaluate hemodynamic, natriuretic, and diuretic responses, as well as to explore potential therapeutic applications in cardiac‑remodeling and cardio‑renal syndromes. It is not intended for diagnostic, therapeutic, or clinical applications in humans or animals.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, Dendroaspis Natriuretic Peptide does not possess established clinical efficacy for therapeutic use in human patients. This synthetic peptide has not undergone clinical development or received regulatory approval for any medical indication. While preclinical studies and early‑phase investigations suggest that DNP or its analogs may offer beneficial effects in heart failure and fluid‑retention states, the product itself remains an investigational tool for basic and translational research. It has no proven clinical efficacy or safety profile in humans and is strictly intended for laboratory research applications.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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