[Tyr0]-C-Type Natriuretic Peptide (32-53) (human, porcine, rat) CAS NO.142878-79-3

[Tyr0]-C-Type Natriuretic Peptide (32-53) (human, porcine, rat) (CAS NO. 142878-79-3, Molecular Formula C₁₀₂H₁₆₆N₂₈O₃₀S₃, Molecular Weight 2360.82 g/mol) is a high-purity research-grade peptide (≥98% RP-HPLC) designed for preclinical studies in cardiovascular, renal, and metabolic disease research; as a potent NPR-B agonist, it triggers cGMP-mediated vasorelaxation, natriuresis, and diuresis while inhibiting cardiac hypertrophy and fibrosis, with preclinical data showing efficacy in hypertension, heart failure, renal dysfunction, and vascular remodeling models, making it a critical reagent for investigating natriuretic peptide signaling and developing novel therapeutics, available in custom bulk quantities with strict quality control (endotoxin <0.1 EU/μg) and optimal storage stability (-20°C short-term, -80°C long-term).

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Tyr0]-C-Type Natriuretic Peptide (32-53) (human, porcine, rat)
CAS NO.	142878-79-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₀₂H₁₆₆N₂₈O₃₀S₃
Molecular Weight	gg/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥1 mg/mL), PBS (pH 7.4), DMSO; slightly soluble in ethanol
Endotoxin	< 1.0 EU/mg
Biological Activity	Binds to NPR-B with high affinity; exhibits natriuretic, diuretic, vasorelaxant and anti-hypertrophic effects
Storage Conditions	-20°C (short-term, 1-2 years); -80°C (long-term, 3-5 years), avoid repeated freeze-thaw
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

[Tyr0]-C-Type Natriuretic Peptide (32-53) (human, porcine, rat) acts as a potent agonist of natriuretic peptide receptor B (NPR-B), a guanylate cyclase-coupled receptor expressed in vascular endothelial cells, cardiomyocytes, and renal tubular cells. Upon binding to NPR-B, it stimulates the production of cyclic guanosine monophosphate (cGMP), a second messenger that triggers downstream signaling cascades. This activation leads to vasorelaxation (dilation of blood vessels), natriuresis (sodium excretion), and diuresis (water excretion), while also inhibiting cardiac hypertrophy, fibrosis, and vascular smooth muscle cell proliferation. The Tyr0 modification enhances peptide stability and receptor binding affinity compared to native CNP (32-53), prolonging its biological half-life and therapeutic efficacy.

2.PRODUCT INDICATIONS

Investigation of hypertension, heart failure, and cardiac hypertrophy mechanisms

Study of renal function regulation, sodium/water homeostasis, and chronic kidney disease (CKD)

Evaluation of vascular remodeling, atherosclerosis, and endothelial dysfunction

Development of novel therapeutics for diabetic nephropathy and metabolic syndrome

Basic research on natriuretic peptide signaling pathways and NPR-B ligand-receptor interactions

3.CLINICAL EFFICACY OF PRODUCT

Investigation of hypertension, heart failure, and cardiac hypertrophy mechanisms

Study of renal function regulation, sodium/water homeostasis, and chronic kidney disease (CKD)

Evaluation of vascular remodeling, atherosclerosis, and endothelial dysfunction

Development of novel therapeutics for diabetic nephropathy and metabolic syndrome

Basic research on natriuretic peptide signaling pathways and NPR-B ligand-receptor interactions

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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