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[Des-Arg30,Des-Pro31]-Dendroaspis Natriuretic Peptide

[Des-Arg30,Des-Pro31]-Dendroaspis Natriuretic Peptide is a synthetic, truncated analog derived from Dendroaspis Natriuretic Peptide (DNP), a peptide originally isolated from green mamba venom. This variant is modified by the removal of two C-terminal amino acids (arginine-30 and proline-31), which alters its pharmacological profile.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Des-Arg³⁰,Des-Pro³¹]-Dendroaspis Natriuretic Peptide
CAS NO.	72629-64-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C169H263N51O54S2
Molecular Weight	3937.42g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥2 mg/mL), 0.1% TFA in water, or dilute acetic acid; slightly soluble in ethanol
Endotoxin	≤5 EU/mg
Biological Activity	Selective agonist for natriuretic peptide receptor-A (NPR-A); EC₅₀ ≈ 0.5–2.0 nM in cGMP accumulation assays.
Storage Conditions	Store at ≤ -20°C in a dry, dark environment.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This analog retains the core structure necessary to bind to natriuretic peptide receptors (primarily NPR-A and NPR-B). The deletion of the two C-terminal residues (Arg30, Pro31) is designed to modify its enzymatic degradation kinetics and receptor interaction profile compared to the native DNP.

2.PRODUCT INDICATIONS

This product is indicated for specialized research in cardiovascular pharmacology and peptide biochemistry. Key applications include: investigating the structural determinants of natriuretic peptide activity and receptor selectivity, studying the degradation pathways and metabolic stability of DNP analogs, serving as a comparative tool to understand the enhanced potency of native DNP, and exploring potential therapeutic mechanisms for conditions like hypertension, heart failure, and renal dysfunction in preclinical models.

3.CLINICAL EFFICACY OF PRODUCT

This is a research compound with no direct clinical use. Its efficacy is defined by its utility as a scientific probe. Studies using such truncated analogs are critical for mapping the "pharmacophore" regions of natriuretic peptides. Understanding how specific deletions affect potency and stability contributes to the rational design of novel, degradation-resistant peptide therapeutics or mimetics targeting the natriuretic peptide system for cardiovascular diseases, a major area of ongoing drug development.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.